Adiponectin Suppresses Metastasis of Nasopharyngeal Carcinoma through Blocking the Activation of NF-κB and STAT3 Signaling
| Autor: | Zongmeng Zhang, Jinlin Du, Qihua Xu, Chaofeng Xing, Yuyu Li, Sujin Zhou, Zhenggang Zhao, Yunping Mu, Zijian (Allan) Zhao, Sumei Cao, Fanghong Li |
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| Rok vydání: | 2022 |
| Předmět: |
STAT3 Transcription Factor
Nasopharyngeal Carcinoma Epithelial-Mesenchymal Transition adiponectin nasopharyngeal carcinoma metastasis STAT3 NF-κB Organic Chemistry Carcinoma NF-kappa B Nasopharyngeal Neoplasms General Medicine Catalysis Computer Science Applications Inorganic Chemistry Gene Expression Regulation Neoplastic Cell Movement Cell Line Tumor Humans Neoplasm Invasiveness Adiponectin Physical and Theoretical Chemistry Receptors Adiponectin Neoplasm Metastasis Molecular Biology Spectroscopy |
| Zdroj: | International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 12729 |
| ISSN: | 1422-0067 |
| Popis: | Adiponectin is an adipocytokine with anti-inflammatory and anticancer properties. Our previous study has shown that blood adiponectin levels were inversely correlated to the risk of nasopharyngeal carcinoma (NPC), and that adiponectin could directly suppress the proliferation of NPC cells. However, the effect of adiponectin on NPC metastasis remains unknown. Here, we revealed in clinical studies that serum adiponectin level was inversely correlated with tumor stage, recurrence, and metastasis in NPC patients, and that low serum adiponectin level also correlates with poor metastasis-free survival. Coculture with recombinant adiponectin suppressed the migration and invasion of NPC cells as well as epithelial–mesenchymal transition (EMT). In addition, recombinant adiponectin dampened the activation of NF-κB and STAT3 signaling pathways induced by adipocyte-derived proinflammatory factors such as leptin, IL-6, and TNF-α. Pharmacological activation of adiponectin receptor through its specific agonist, AdipoRon, largely stalled the metastasis of NPC cells. Taken together, these findings demonstrated that adiponectin could not only regulate metabolism and inhibit cancer growth, but also suppress the metastasis of NPC. Pharmacological activation of adiponectin receptor may be a promising therapeutic strategy to stall NPC metastasis and extend patients’ survival. |
| Databáze: | OpenAIRE |
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