Intrahepatic cholangiocarcinoma in a low endemic area: rising incidence and improved survival
| Autor: | Robert A. de Man, Jan N. M. IJzermans, Henrike E. Karim-Kos, Esther de Vries, Jan Willem Coebergh, Cornelis Verhoef, Otto Visser, Caroline D.M. Witjes |
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| Přispěvatelé: | Surgery, Public Health, Internal Medicine, Gastroenterology & Hepatology |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Endemic Diseases Gastroenterology Risk Assessment Cholangiocarcinoma Age Distribution Sex Factors SDG 3 - Good Health and Well-being Risk Factors Internal medicine medicine Humans Registries Sex Distribution Survival analysis Intrahepatic Cholangiocarcinoma Aged Neoplasm Staging Netherlands Relative survival Hepatology business.industry Incidence (epidemiology) Incidence Liver Neoplasms Age Factors Endemic area Original Articles Middle Aged Prognosis Survival Analysis Confidence interval Cancer registry Bile Ducts Intrahepatic Bile Duct Neoplasms Lymphatic Metastasis Etiology Female business |
| Zdroj: | HPB, 14(11), 777-781. John Wiley & Sons Inc. |
| ISSN: | 1365-182X |
| DOI: | 10.1111/j.1477-2574.2012.00536.x |
| Popis: | Background: To explore trends in the incidence and survival of patients with intrahepatic cholangiocarcinoma (ICC) an unselected population in Western Europe was studied. Methods: Between 1989 and 2009, all patients newly diagnosed with ICC were selected from the Netherlands Cancer Registry (n= 809). Trends in incidence, treatment and relative survival were calculated according to gender and age. Follow-up for vital status was complete until 1st January 2010. Results: The incidence rates of ICC increased significantly between 1999 and 2009, especially in the age group 45-59 years [estimated annual percentage change +3.0%, 95% confidence interval (CI) 0.2-5.8]. In the other age groups ICC incidence remained stable. Patients diagnosed with Tumour Lymph Node Metastasis (TNM) stage I mainly underwent surgery (68%), and the majority of the patients with stage II, III and IV received best supportive care (73%). One-year relative survival for patients with ICC increased significantly from 24% in 1989-1994 to 28% in 2005-2009 (P= 0.03), and corresponding 3-year relative survival improved from 4% to 8% (P= 0.02). Three-month and 1-year relative survival for patients with ICC receiving surgery was 91% and 71%, respectively. Discussion: Between 1999 and 2009, the incidence of ICC rose, especially in the age group 45-59 years, suggesting aetiological influences. Survival rates have improved during the study period. |
| Databáze: | OpenAIRE |
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