Paratesticular rhabdomyosarcoma-Impact of locoregional approach on patient outcome: A report from the European paediatric Soft tissue sarcoma Study Group (EpSSG)
| Autor: | Gianni Bisogno, Ross J. Craigie, Anna Kelsey, Gabriela Guillén Burrieza, Gian Luca De Salvo, Timothy Rogers, Hélène Martelli, Beatrice Coppadoro, Florent Guérin, Naima Smeulders, Meriel Jenney, Federica De Corti, Ilaria Zanetti, Sheila Terwisscha van Scheltinga |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment paratesticular Malignancy Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Testicular Neoplasms Median follow-up Rhabdomyosarcoma medicine Humans In patient Child Chemotherapy business.industry Soft tissue sarcoma Significant difference Infant Hematology medicine.disease Surgery Survival Rate pediatric Oncology 030220 oncology & carcinogenesis Paratesticular rhabdomyosarcoma Child Preschool Pediatrics Perinatology and Child Health Guideline Adherence business rhabdomyosarcoma 030215 immunology Follow-Up Studies |
| Zdroj: | Pediatric bloodcancerREFERENCES. 67(9) |
| ISSN: | 1545-5017 |
| Popis: | BACKGROUND Paratesticular rhabdomyosarcoma (PT RMS) is rare compared to benign scrotal pathology. Inappropriate first surgery (InFS) required supplementary treatment to maintain excellent outcomes. Initial staging of regional lymph nodes is important. The aim of this study was to determine to what extent the quality of locoregional approach impacted on patient morbidity and survival. DESIGN/METHODS Analysis was performed on all nonmetastatic PT RMS patients enrolled in the European paediatric Soft tissue sarcoma Study Group (EpSSG) RMS 2005 protocol. Aspects assessed were adherence to surgical guidelines and impact of protocol violations, relapse analysis, and survival outcomes. RESULTS Analysis was performed on 237 patients, with median follow up of 67.1 months. Median age was 9.0 years. InFS occurred in 75 of 237 (32%) patients. InFS required intensified chemotherapy (10) and local therapy. After InFS, 61 required primary reexcision and five delayed surgery. Of 26 recurrences, the risk of relapse was higher in patients ≥10 years (21/26) and was mainly locoregional in 16 of 26 recurrences (± metastatic). Sixteen of 26 died with 14 of 16 patients ≥10 years. Nodal relapse neither occurred when N1 nodes were identified at diagnosis, nor after surgical staging. Five-year overall survival (OS) at age |
| Databáze: | OpenAIRE |
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