Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice
| Autor: | Hugues Wallemacq, Nico van Rooijen, Alain Vanderplasschen, Benjamin G Dewals, Muriel Moser, Alain Le Moine, Florence Quesada Calvo, Pierre Lekeux, Caroline Thielen, Christophe Desmet, Denis Bedoret, R. Closset, Fabrice Bureau, Pascal Gustin, Didier Cataldo, Pierre-Vincent Drion, Emmanuelle Henry, Laurence de Leval, Thomas Marichal |
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| Přispěvatelé: | Molecular cell biology and Immunology, CCA - Immuno-pathogenesis |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Lipopolysaccharides
Allergy Ovalbumin Cell Population Molecular Sequence Data Mice Transgenic Biology Adaptive Immunity Mice Th2 Cells Antigen In vivo Cell Movement Macrophages Alveolar medicine Animals Amino Acid Sequence education Lung Mice Knockout education.field_of_study Mice Inbred BALB C Macrophages Cell Differentiation General Medicine Dendritic cell Dendritic Cells Allergens medicine.disease Asthma Immunity Innate Peptide Fragments Interleukin-10 Mice Inbred C57BL Toll-Like Receptor 4 medicine.anatomical_structure Immunology Respiratory tract Research Article |
| Zdroj: | Journal of Clinical Investigation, 119(12), 3723-3738. The American Society for Clinical Investigation Bedoret, D, Wallemacq, H, Marichal, T, Desmet, C, Calvo, F Q, Henry, E, Closset, R, Dewals, B, Thielen, C, Gustin, P, de Leval, L, van Rooijen, N, Le Moine, A, Vanderplasschen, A, Cataldo, D, Drion, P V, Moser, M B, Lekeux, P & Bureau, F 2009, ' Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice ', Journal of Clinical Investigation, vol. 119, no. 12, pp. 3723-3738 . https://doi.org/10.1172/JCI39717 |
| ISSN: | 0021-9738 |
| Popis: | The respiratory tract is continuously exposed to both innocuous airborne antigens and immunostimulatory molecules of microbial origin, such as LPS. At low concentrations, airborne LPS can induce a lung DC-driven Th2 cell response to harmless inhaled antigens, thereby promoting allergic asthma. However, only a small fraction of people exposed to environmental LIPS develop allergic asthma. What prevents most people from mounting a lung DC-driven Th2 response upon exposure to LPS is not understood. Here we have shown that lung interstitial macrophages (IMs), a cell population with no previously described in vivo function, prevent induction of a Th2 response in mice challenged with LPS and an experimental harmless airborne antigen. IMs, but not alveolar macrophages, were found to produce high levels of IL-10 and to inhibit LPS-induced maturation and migration of DCs loaded with the experimental harmless airborne antigen in an IL-10-dependent manner. We further demonstrated that specific in vivo elimination of IMs led to overt asthmatic reactions to innocuous airborne antigens inhaled with low doses of LPS. This study has revealed a crucial role for IMs in maintaining immune homeostasis in the respiratory tract and provides an explanation for the paradox that although airborne LPS has the ability to promote the induction of Th2 responses by lung DCs, it does not provoke airway allergy under normal conditions |
| Databáze: | OpenAIRE |
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