Distribution of genetic alterations in high-risk early-stage cervical cancer patients treated with postoperative radiation therapy
| Autor: | Kae Okuma, Shotaro Yamano, Kuniko Sunami, Jun Itami, Tomoyasu Kato, Hiroshi Yoshida, Yuka Asami, Kazuaki Takahashi, Naoya Murakami, Yoko Shimada, Maiko Matsuda, Takayuki Honda, Sou Hirose, Takashi Kohno, Tomomi Nakahara, Ikumi Kuno, Daisuke Takayanagi, Takafumi Kuroda, Kouya Shiraishi, Tomoko Watanabe |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_treatment Uterine Cervical Neoplasms medicine.disease_cause 0302 clinical medicine AMP-Activated Protein Kinase Kinases Japan Parametrium Stage (cooking) Cancer Cervical cancer Mutation Multidisciplinary Genomics Middle Aged medicine.anatomical_structure 030220 oncology & carcinogenesis Medicine Female Adult medicine.medical_specialty Class I Phosphatidylinositol 3-Kinases Tumour heterogeneity Science Protein Serine-Threonine Kinases Hysterectomy Article 03 medical and health sciences Germline mutation Internal medicine medicine Humans Radical Hysterectomy Aged Retrospective Studies Radiotherapy business.industry PTEN Phosphohydrolase Oncogenes medicine.disease Radiation therapy 030104 developmental biology Radiotherapy Intensity-Modulated Tumor Suppressor Protein p53 business |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Somatic genetic alteration analysis was performed for post-hysterectomy high-risk early-stage uterine cervical cancer patients who underwent post-operative radiation therapy. Post-operative radiation therapy was performed for patients with pathological features of pelvic lymph node metastasis, parametrium invasion, or positive vaginal margin, which corresponded to the post-operative high-risk category. DNA was extracted from paraffin-embedded surgical specimens, and 50 somatic hotspot genetic alternations were detected using Ion AmpliSeq Cancer Hotspot Panel. The existence of actionable mutation was assessed based on OncoKB evidence level > 3A. Between January 2008 and November 2019, 89 patients who underwent abdominal radical hysterectomy followed by post-operative radiation therapy were identified. The follow-up period for living patients was 82.3 months (range 9.3–153.9), and the 5-year relapse-free survival and overall survival rates were 72.6% and 85.9%, respectively. The most frequently detected somatic mutation was PIK3CA (26 [29.2%] patients); however, no prognostic somatic genetic alterations were identified. Actionable mutations were detected in 30 (33.7%) patients. Actionable mutations were detected in approximately one-third of patients, suggesting that precision medicine can be offered to patients with post-operative high-risk uterine cervical cancer in the near future. |
| Databáze: | OpenAIRE |
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