The effects of hydroxycinnamic acid derivatives on adiponectin secretion

Autor: Toshiaki Ohshima, Hideki Ushio, Kazuyuki Ohara, Reiko Nagasaka, Asako Uchida
Rok vydání: 2008
Předmět:
Lipopolysaccharides
Male
medicine.medical_treatment
Pharmaceutical Science
medicine.disease_cause
chemistry.chemical_compound
Mice
Adipocyte
Drug Discovery
Adipocytes
Adiponectin secretion
Hypolipidemic Agents
chemistry.chemical_classification
Phenylpropionates
NF-kappa B
Phenylethyl Alcohol
Hydroxycinnamic acid
Molecular Medicine
Adiponectin
hormones
hormone substitutes
and hormone antagonists
medicine.drug
medicine.medical_specialty
Curcumin
Coumaric Acids
Biology
Rice Bran Oil
Interferon-gamma
Insulin resistance
Caffeic Acids
Internal medicine
3T3-L1 Cells
medicine
Animals
Hypoglycemic Agents
Plant Oils
Pharmacology
Pioglitazone
Plant Extracts
Tumor Necrosis Factor-alpha
Insulin
nutritional and metabolic diseases
medicine.disease
Mice
Inbred C57BL
Endocrinology
Complementary and alternative medicine
chemistry
Diabetes Mellitus
Type 2
Thiazolidinediones
Insulin Resistance
Oxidative stress
Phytotherapy
Zdroj: Phytomedicine : international journal of phytotherapy and phytopharmacology. 16(2-3)
ISSN: 1618-095X
Popis: Adiponectin is positively correlated with insulin sensitivity. Hydroxycinnamic acid derivatives (HADs), observed ubiquitously in plants, have some physiological functions. In this study, we investigated the effect of HADs on serum adiponectin concentrations in mice and on adiponectin secretion of 3T3-L1 adipocytes. In mice, serum adiponectin concentrations were increased by gamma-oryzanol administration. CAPE, curcumin, and trans-ferulic acid markedly enhanced the adiponectin secretion of 3T3-L1 adipocytes, but not gamma-oryzanol. To clarify the effects of gamma-oryzanol in mice or the effects of HADs on the underlying mechanisms of adiponectin secretion, we further investigated the effect of HADs on adiponectin secretion in the NF-kappaB activation state. Although the adiponectin secretion was reduced in the presence of lipopolysaccharide plus TNF-alpha and IFN-gamma, only gamma-oryzanol supported the activity of adiponectin secretion under NF-kappaB activated condition. The results indicate that these HADs might regulate adiponectin secretion by the inhibition of NF-kappaB activation. HADs might be effective for ameliorating type 2 diabetes.
Databáze: OpenAIRE
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