Presence of antidrug antibodies correlates inversely with the plasma tumor necrosis factor (TNF)-α level and the efficacy of TNF-inhibitor therapy in psoriasis
| Autor: | Brigitta Gál, Rolland Gyulai, Róbert Kui, Magdolna Gaál, Mária Kiss, Lajos Kemény |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty medicine.medical_treatment Dermatology Severity of Illness Index Gastroenterology Etanercept Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine Psoriasis medicine Adalimumab Humans Clinical severity skin and connective tissue diseases Aged 030203 arthritis & rheumatology biology Tumor Necrosis Factor-alpha business.industry General Medicine Middle Aged medicine.disease Antibodies Neutralizing Infliximab TNF inhibitor Biological Therapy Cross-Sectional Studies Treatment Outcome Immunology biology.protein Female Tumor necrosis factor alpha Dermatologic Agents Antibody business medicine.drug |
| Zdroj: | The Journal of Dermatology. 43:1018-1023 |
| ISSN: | 0385-2407 |
| DOI: | 10.1111/1346-8138.13301 |
| Popis: | Antidrug antibodies have been shown to be associated with a loss of response during biologic therapy. Despite the potential association, there has been no report on the simultaneous monitoring of the following parameters in psoriasis: presence of neutralizing antibodies, plasma tumor necrosis factor (TNF)-α concentration, TNFi concentration and disease activity. Plasma concentrations of adalimumab, infliximab, etanercept and their respective antidrug antibodies, as well as plasma concentrations of TNF-α were measured in 77 psoriasis patients receiving biologic therapy, and the values were correlated with the clinical activity of the skin disease. Antidrug antibodies were identified in the plasma of 25% of infliximab-treated patients and 29.6% of adalimumab-treated patients, but not in the etanercept group. Clinical severity scores were significantly higher in the antibody-positive patients. In patients receiving infliximab or adalimumab therapy, the presence of antidrug antibodies was directly associated with reduced plasma TNF-inhibitor concentration and elevated plasma TNF-α level. |
| Databáze: | OpenAIRE |
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