Symptom remission at 12-weeks strongly predicts long-term recovery from the first episode of psychosis
| Autor: | Gillian A. Doody, Margaret Heslin, Peter B. Jones, Adanna Onyejiaka, Robin M. Murray, Ben Lomas, Tim Croudace, Julia Lappin, Kim Donoghue, Paola Dazzan, Craig Morgan, Ulrich Reininghaus, Paul Fearon |
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| Přispěvatelé: | Dazzan, Paola [0000-0002-8427-3617], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Population clinical outcome functional outcome Young Adult 03 medical and health sciences remission 0302 clinical medicine Internal medicine Activities of Daily Living Outcome Assessment Health Care Epidemiology Humans Medicine psychosis Bipolar disorder Young adult education Depression (differential diagnoses) Applied Psychology Psychiatric Status Rating Scales First episode education.field_of_study Clinical outcome business.industry Remission Induction Original Articles medicine.disease United Kingdom 030227 psychiatry schizophrenia Psychiatry and Mental health Logistic Models Psychotic Disorders Cohort Schizophrenia Female Schizophrenic Psychology medicine.symptom business Mania 030217 neurology & neurosurgery Antipsychotic Agents Follow-Up Studies |
| Zdroj: | Dazzan, P, Lappin, J M, Heslin, M, Donoghue, K, Lomas, B, Reininghaus, U, Onyejiaka, A, Croudace, T, Jones, P, Murray, R M, Fearon, P, Doody, G & Morgan, C 2019, ' Symptom remission at 12-weeks strongly predicts long-term recovery from the first episode of psychosis ', Psychological Medicine . https://doi.org/10.1017/S0033291719001399 Psychological Medicine |
| ISSN: | 0033-2917 1469-8978 |
| Popis: | BackgroundTo determine the baseline individual characteristics that predicted symptom recovery and functional recovery at 10-years following the first episode of psychosis.MethodsAESOP-10 is a 10-year follow up of an epidemiological, naturalistic population-based cohort of individuals recruited at the time of their first episode of psychosis in two areas in the UK (South East London and Nottingham). Detailed information on demographic, clinical, and social factors was examined to identify which factors predicted symptom and functional remission and recovery over 10-year follow-up. The study included 557 individuals with a first episode psychosis. The main study outcomes were symptom recovery and functional recovery at 10-year follow-up.ResultsAt 10 years, 46.2% (n= 140 of 303) of patients achieved symptom recovery and 40.9% (n= 117) achieved functional recovery. The strongest predictor of symptom recovery at 10 years was symptom remission at 12 weeks (adj OR 4.47; CI 2.60–7.67); followed by a diagnosis of depression with psychotic symptoms (adj OR 2.68; CI 1.02–7.05). Symptom remission at 12 weeks was also a strong predictor of functional recovery at 10 years (adj OR 2.75; CI 1.23–6.11), together with being from Nottingham study centre (adj OR 3.23; CI 1.25–8.30) and having a diagnosis of mania (adj OR 8.17; CI 1.61–41.42).ConclusionsSymptom remission at 12 weeks is an important predictor of both symptom and functional recovery at 10 years, with implications for illness management. The concepts of clinical and functional recovery overlap but should be considered separately. |
| Databáze: | OpenAIRE |
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