Breast radiologic complete response is associated with favorable survival outcomes after neoadjuvant chemotherapy in breast cancer
| Autor: | Seok Won Kim, Sung Mi Jung, Se Kyung Lee, Jeong Eon Lee, Jonghan Yu, Jinsun Woo, Jai Min Ryu, Byung Joo Chae, Seok Jin Nam, Hee Jun Choi |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Oncology medicine.medical_specialty medicine.medical_treatment Antineoplastic Agents Breast Neoplasms 030230 surgery Survival outcome Young Adult 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Republic of Korea medicine Axillary nodes Overall survival Humans Breast skin and connective tissue diseases Complete response Aged Neoplasm Staging Retrospective Studies Chemotherapy Kappa value business.industry General Medicine Middle Aged Prognosis medicine.disease Magnetic Resonance Imaging Neoadjuvant Therapy Survival Rate Chemotherapy Adjuvant 030220 oncology & carcinogenesis Female Surgery business |
| Zdroj: | European Journal of Surgical Oncology. 47:232-239 |
| ISSN: | 0748-7983 |
| DOI: | 10.1016/j.ejso.2020.08.023 |
| Popis: | Background The aim of this study was to examine the accuracy of radiologic complete response (rCR) in predicting pathologic complete response (pCR), and determine whether rCR is a predictor of favorable survival outcomes. Materials and methods We retrospectively reviewed breast cancer patients treated with neoadjuvant chemotherapy (NAC) followed by surgery from September 2007 to June 2016. Breast lesions and axillary nodes were measured by MRI and categorized into either disappeared (breast rCR) or residual disease (breast non-rCR) and either normalized (axillary rCR) or abnormal findings (axillary non-rCR) in the axillary nodes. Correlation between rCR and pCR were compared using Cohen’s Kappa statistics, and the recurrence-free survival (RFS) and overall survival (OS) rates were calculated by the Kaplan-Meier method. Results Out of the 1017 eligible patients, 287 (28.2%) achieved breast pCR, 165 (16.2%) achieved breast rCR, 529 (52.0%) had axillary pCR, and 274 (26.9%) achieved axillary rCR. The correlation between a breast rCR and pCR showed a Cohen’s Kappa value of 0.459, and between axillary rCR and pCR, the value was 0.384. During a median follow-up time of 48.0 months, the 5-year RFS rates were 90.6% for breast rCR, and 69.2% for breast non-rCR. The 5-year RFS rates were 82.3% for axillary rCR, and 68.8% for axillary non-rCR. Patients without breast rCR had a 2.4-fold significant increase in the risk of recurrence (p = 0.004) compared to patients with breast rCR. Conclusion Although rCR correlated with pCR by only moderate to fair degrees, breast rCR was a strong predictor for a favorable RFS outcome. |
| Databáze: | OpenAIRE |
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