Free fatty acids increase hepatic glycogen content in obese males
| Autor: | G. Allick, H. P. Sauerwein, M. T. Ackermans, Johannes A. Romijn, Fleur Sprangers, P.H.L.T. Bisschop, G. J. Weverling, E. Endert, A.J. Meijer |
|---|---|
| Přispěvatelé: | Paediatric Neurology, Other Research, Laboratory for Endocrinology, Medical Biochemistry, Other departments, Endocrinology |
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Acipimox Glycogenolysis Glucuronate Endocrinology Diabetes and Metabolism Fatty Acids Nonesterified Biology Gas Chromatography-Mass Spectrometry chemistry.chemical_compound Endocrinology Internal medicine medicine Humans Insulin Lipolysis Obesity Glycogen synthase Hypolipidemic Agents C-Peptide Glycogen Increased hepatic glycogen content Gluconeogenesis Fasting Middle Aged Hormones Stimulation Chemical Liver Glycogen Glucose chemistry Glycogenesis Pyrazines biology.protein medicine.drug |
| Zdroj: | Metabolism: clinical and experimental, 53(7), 886-893. W.B. Saunders Ltd |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/j.metabol.2004.01.012 |
| Popis: | Obesity is associated with increased hepatic glycogen content. In vivo and in vitro data suggest that plasma free fatty acids (FFA) may cause this increase. In this study we investigated the effect of physiological plasma FFA levels on hepatic glycogen metabolism by studying intrahepatic glucose pathways in lean and obese subjects. Six lean and 6 obese males were studied twice during a 16- to 22-hour fast, once with and once without acipimox, an inhibitor of lipolysis. Intrahepatic glucose fluxes were measured by infusion of [2-C-13(1)]glycerol, [1-H-2(1)]galactose, and [U-C-13(6)]glucose. Acetaminophen was administered as a glucuronate probe. In both lean and obese control studies, plasma FFA levels increased progressively, whereas acipimox completely suppressed plasma FFA levels for the whole study period. In lean males glycogenolysis did not change in the acipimox study, but decreased in the control study (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect