Temperament and prodromal symptoms prior to first manic/hypomanic episodes: Results from a pilot study
| Autor: | Eike Zeschel, Michael Bauer, Tiffany Bingmann, Andrea Pfennig, Andreas Bechdolf, Seza Krüger-Oezguerdal, Karolina Leopold, Georg Juckel, Christoph U. Correll |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Predictive validity medicine.medical_specialty Psychosis Bipolar Disorder media_common.quotation_subject Prodromal Symptoms Pilot Projects Prodrome Young Adult medicine Humans Bipolar disorder Temperament Psychiatry Retrospective Studies media_common First episode medicine.disease Irritable Mood Psychiatry and Mental health Clinical Psychology Hypomania Female medicine.symptom Psychology Mania Clinical psychology |
| Zdroj: | Journal of Affective Disorders. 173:39-44 |
| ISSN: | 0165-0327 |
| DOI: | 10.1016/j.jad.2014.10.031 |
| Popis: | Background Prodromal symptoms prior to first episode mania/hypomania have been reported. However, the relationship between temperament and manic/hypomanic prodromal symptoms has not been investigated. We hypothesized that subjects scoring higher on cyclothymic and irritable temperament scales show more manic/hypomanic prodromal symptoms. Method Euthymic patients diagnosed with bipolar-I or -II disorder within 8 years underwent retrospective assessments with the Temperament Evaluation of Memphis, Pisa, Paris and San Diego-autoquestionnaire (TEMPS-A) and the Bipolar Prodrome Symptom Scale-Retrospective (BPSS-R). Results Among 39 subjects (36.1±9.9 years, females=59%, bipolar-I=62%) 100% and 92.3% reported subthreshold mania (mean=7.4±2.9) or subthreshold depressive symptoms (mean=2.4±1.5), and 87.2% and 43.6% reported general psychopathology (mean=3.2±2.0) or subthreshold psychotic symptoms (mean=0.7±1.0) prior to their first hypo-/manic episode. Subjects with higher cyclothymic and irritable temperament scores showed more subthreshold symptoms prior to the first manic/hypomanic episode, mainly subthreshold hypo-/manic symptoms (cyclothymic temperament r =0.430; p =0.006; irritable temperament r =0.330; p =0.040), general psychopathology symptoms (cyclothymic temperament r =0.316; p =0.05; irritable temperament r =0.349; p =0.029) and subthreshold psychotic symptoms (cyclothymic temperament r =0.413; p =0.009). In regression analyses, cyclothymic temperament explained 16.1% and 12.5% of the variance of the BPSS-R total score ( p =0.045) and psychosis subscore ( p =0.029). Limitations Retrospective study, no control group, small sample size. Conclusion We present data, which indicate a relationship between cyclothymic and irritable temperament and prodromal symptoms prior to the first manic/hypomanic episode. These findings support the notion that assessing cyclothymic temperament to identify people at-risk of developing bipolar-I and -II disorder may help to increase the predictive validity of applied at-risk criteria. |
| Databáze: | OpenAIRE |
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