NMDA Receptor Antagonist Ketamine Impairs Feature Integration in Visual Perception

Autor: Anouk M. van Loon, Victor A. F. Lamme, Markus W. Hollmann, Nienke Vulink, H. Steven Scholte, Philipp Lirk, Julia D. I. Meuwese
Přispěvatelé: Other Research, Anesthesiology, Amsterdam Neuroscience, Adult Psychiatry, Amsterdam Cardiovascular Sciences, Amsterdam institute for Infection and Immunity, Faculteit der Geneeskunde, Brein en Cognitie (Psychologie, FMG), Cognitive Psychology, IBBA
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Male
Visual perception
SDG 16 - Peace
media_common.quotation_subject
Sedation
lcsh:Medicine
Research Support
Receptors
N-Methyl-D-Aspartate
03 medical and health sciences
Young Adult
0302 clinical medicine
Perception
Receptors
medicine
Journal Article
Humans
Ketamine
Controlled Clinical Trial
Non-U.S. Gov't
lcsh:Science
030304 developmental biology
media_common
0303 health sciences
Multidisciplinary
business.industry
Research Support
Non-U.S. Gov't
lcsh:R
SDG 16 - Peace
Justice and Strong Institutions
Justice and Strong Institutions
Healthy Volunteers
Visual cortex
medicine.anatomical_structure
Feature (computer vision)
Anesthesia
Fixation (visual)
Visual Perception
NMDA receptor
lcsh:Q
Female
medicine.symptom
business
Neuroscience
030217 neurology & neurosurgery
Research Article
medicine.drug
N-Methyl-D-Aspartate
Zdroj: PLoS ONE
Meuwese, J D I, van Loon, A M, Scholte, H S, Lirk, P B, Vulink, N C C, Hollmann, M W & Lamme, V A F 2013, ' NMDA receptor antagonist ketamine impairs feature integration in visual perception ', PLoS ONE, vol. 8, no. 11, pp. e79326 . https://doi.org/10.1371/journal.pone.0079326
PLoS ONE, Vol 8, Iss 11, p e79326 (2013)
PLoS ONE, 8(11). Public Library of Science
PLoS ONE, 8(11):e79326. Public Library of Science
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0079326
Popis: Recurrent interactions between neurons in the visual cortex are crucial for the integration of image elements into coherent objects, such as in figure-ground segregation of textured images. Blocking N-methyl-D-aspartate (NMDA) receptors in monkeys can abolish neural signals related to figure-ground segregation and feature integration. However, it is unknown whether this also affects perceptual integration itself. Therefore, we tested whether ketamine, a non-competitive NMDA receptor antagonist, reduces feature integration in humans. We administered a subanesthetic dose of ketamine to healthy subjects who performed a texture discrimination task in a placebo-controlled double blind within-subject design. We found that ketamine significantly impaired performance on the texture discrimination task compared to the placebo condition, while performance on a control fixation task was much less impaired. This effect is not merely due to task difficulty or a difference in sedation levels. We are the first to show a behavioral effect on feature integration by manipulating the NMDA receptor in humans.
Databáze: OpenAIRE
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