Production of Monoclonal Antibody SP-21 to Colon-Ovarian Tumor Antigen, COTA
| Autor: | T.A. Stewart, B.A. Rhodes, K.D. Pant, C.O.A. Berry |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
medicine.drug_class
Immunology Mice Inbred Strains Monoclonal antibody Chromatography Affinity Rats Mutant Strains Immunoenzyme Techniques Mice Ovarian tumor Antigen Antibody Specificity Antigens Neoplasm ABO blood group system Genetics Animals Medicine Hybridomas biology Histocytochemistry Rectal Neoplasms business.industry Mucin Antibodies Monoclonal Molecular biology digestive system diseases Tumor antigen Rats Polyclonal antibodies Colonic Neoplasms biology.protein Female Antibody business |
| Zdroj: | Hybridoma. 5:129-135 |
| ISSN: | 0272-457X |
| DOI: | 10.1089/hyb.1986.5.129 |
| Popis: | An IgG monoclonal antibody, SP-21, directed against colon-ovarian tumor antigen, COTA, is reported. The antibody had no reactivity with CEA, normal colonic mucin, CSAp, ABO blood group antigens, or with normal human lung, liver, spleen, kidney, plasma and saliva in studies using the enzyme-linked immunoassay method (ELISA). Immunoperoxidase staining of colon, lung, kidney, and prostate cancer tissues and benign and inflammatory colon disease tissues revealed a specificity identical to that of the polyclonal (goat) anti-COTA antibodies. |
| Databáze: | OpenAIRE |
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