Identification of a novel HLA-DPB1 allele, DPB1*9701, by sequence-based typing
| ISSN: | 0001-2815 |
|---|---|
| Přístupová URL adresa: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600621b3d586ccada574ec0c8f160cb8 https://pubmed.ncbi.nlm.nih.gov/15140044 |
| Rights: | CLOSED |
| Přírůstkové číslo: | edsair.doi.dedup.....600621b3d586ccada574ec0c8f160cb8 |
| Autor: | Mauro Pistello, Simone Lapi, Francesca Bonci, M. L. Mariotti, Patrizia Isola, M. Curcio, Fabrizio Scatena, S Fornaciari |
| Rok vydání: | 2004 |
| Předmět: |
Genetics
HLA-DP Antigens HLA-DPB1 Base Sequence Accession number (library science) Immunology Genetic analysis Molecular Sequence Data Nucleic acid sequence General Medicine Human leukocyte antigen Biology Biochemistry Molecular biology HLA GenBank Immunology and Allergy Humans Typing Allele Sequence Alignment HLA-DP beta-Chains |
| Zdroj: | Tissue antigens. 63(6) |
| ISSN: | 0001-2815 |
| Popis: | This report describes the identification of a novel DPB1 allele, DPB *9701, found in an Italian Caucasian individual. The new allele was detected by human leukocyte antigen sequence-based typing carried out to investigate the role of genetic factors in determining the outcome of hepatitis C virus infection. DPB1*9701 was identical to DPB1*0501 except for a single-nucleotide substitution at codon 43 (GGG --> TGG). This nucleotide change is a non-synonymous mutation and results in the amino acid substitution glycine (G) --> tryptophan (W). The nucleotide sequence has been deposited in GenBank under the accession number AY033075, and denominated DPB1*9701 by the official World Health Organization Nomenclature Committee. |
| Databáze: | OpenAIRE |
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