HLA antigens influence resistance to lung carcinoma
| Autor: | John A. Stryker, Paula J. Romano, J. Houck, F. Kloszewski, Philip J. Smith, Elliot S. Vessell, Mary Bartholomew |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Lung Neoplasms Immunology Human leukocyte antigen Biology Major histocompatibility complex Pathogenesis Sex Factors HLA Antigens Carcinoma medicine Immunology and Allergy Humans Lung cancer Lung Epithelioma Respiratory disease Smoking General Medicine respiratory system medicine.disease Immunity Innate respiratory tract diseases medicine.anatomical_structure biology.protein Female Disease Susceptibility |
| Zdroj: | Human immunology. 31(4) |
| ISSN: | 0198-8859 |
| Popis: | The concept of genetic factors playing a role in the pathogenesis of lung cancer has gained increased attention. The present study was undertaken to reexamine the question of HLA antigen association with carcinoma of the lung. In a study of 90 patients, a significant association occurred between HLA-DR7 and resistance to lung cancer, after accounting for smoking status and sex. HLA class I antigens were also implicated. These results suggest that major histocompatibility complex loci affect carcinoma of the lung. |
| Databáze: | OpenAIRE |
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