Concurrent use of Chinese herbal medicine among hormone users and its association with ischemic stroke risk: A population-based study
Autor: | Mun-Kun Hong, Shu-Hui Wen, Wei-Chuan Chang, Hsien-Chang Wu |
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Rok vydání: | 2018 |
Předmět: |
Adult
medicine.medical_specialty Time Factors Multivariate analysis Databases Factual Hormone Replacement Therapy medicine.medical_treatment Taiwan Lower risk Risk Assessment Brain Ischemia 03 medical and health sciences Sex Factors 0302 clinical medicine Risk Factors Internal medicine Drug Discovery Humans Medicine Propensity Score Stroke Aged Proportional Hazards Models Retrospective Studies Pharmacology Chi-Square Distribution 030219 obstetrics & reproductive medicine business.industry Proportional hazards model Incidence Hazard ratio Age Factors Middle Aged Protective Factors medicine.disease Menopause 030220 oncology & carcinogenesis Multivariate Analysis Female Hormone therapy business Administrative Claims Healthcare Drugs Chinese Herbal Hormone |
Zdroj: | Journal of Ethnopharmacology. 216:274-282 |
ISSN: | 0378-8741 |
Popis: | Previous studies had indicated that hormone therapy (HT) may increase the risk of ischemic stroke (IS) in menopausal women. However, little is known about the benefits and risks of use of Chinese herbal medicine (CHM) in conditions related to hormone use. The aim of this study is to explore the risk of IS in menopausal women treated with HT and CHM.A total of 32,441 menopausal women without surgical menopause aged 40-65 years were selected from 2003 to 2010 using the 2-million random samples of the National Health Insurance Research Database in Taiwan. According to the medication usage of HT and CHM, we divided the current and recent users into two groups: an HT use-only group (n = 4989) and an HT/CHM group (n = 9265). Propensity-score matching samples (4079 pairs) were further created to deal with confounding by indication. The adjusted hazard ratios (HR) of IS were estimated by the robust Cox proportional hazards model.The incidence rate of IS in the HT/CHM group was significantly lower than in the HT group (4.5 vs. 12.8 per 1000 person-year, p 0.001). Multivariate analysis results indicated that additional CHM use had a lower risk of IS compared to the HT group (HR = 0.3; 95% confidence interval [CI], 0.21-0.43). Further subgroup analyses and sensitivity analyses had similar findings.We found that combined use of HT and CHM was associated with a lower risk of IS. Further study is needed to examine possible mechanism underlying this association. |
Databáze: | OpenAIRE |
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