Wound Repair, Scar Formation, and Cancer: Converging on Activin
| Autor: | Mateusz S. Wietecha, Michael Cangkrama, Sabine Werner |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cell type medicine.disease_cause Cicatrix 03 medical and health sciences 0302 clinical medicine Neoplasms Animals Humans Medicine Fibroblast Molecular Biology Wound Healing business.industry Cancer Fibroblasts medicine.disease Tumor formation Activins 030104 developmental biology medicine.anatomical_structure Cancer research Molecular Medicine Disease Susceptibility business Wound healing Carcinogenesis Biomarkers hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery |
| Zdroj: | Trends in Molecular Medicine. 26:1107-1117 |
| ISSN: | 1471-4914 |
| DOI: | 10.1016/j.molmed.2020.07.009 |
| Popis: | Wound repair is a highly regulated process that requires the interaction of various cell types. It has been shown that cancers use the mechanisms of wound healing to promote their own growth. Therefore, it is of importance to identify common regulators of wound repair and tumor formation and to unravel their functions and mechanisms of action. An exciting example is activin, which acts on multiple cell types in wounds and tumors, thereby promoting healing, but also scar formation and tumorigenesis. Here, we summarize current knowledge on the role of activin in these processes and highlight the therapeutic potential of activin or activin antagonists for the treatment of impaired healing or excessive scarring and cancer, respectively. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect