Aging and oxidative stress
| Autor: | Silvia Berlanga de Moraes Barros, Virginia Junqueira, Sandra S. Chan, Luciano Miller Reis Rodrigues, Guilherme P. Deucher, Leandro Giavarotti, Ronaldo L. Abud |
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| Rok vydání: | 2004 |
| Předmět: |
Aging
Antioxidant medicine.medical_treatment Clinical Biochemistry Physiology medicine.disease_cause Biochemistry Antioxidants medicine TBARS Animals Humans Molecular Biology Organism chemistry.chemical_classification biology Chemistry Glutathione peroxidase Proteins DNA General Medicine Plasma levels Lipid Metabolism Ascorbic acid Oxidative Stress Catalase biology.protein Molecular Medicine Oxidative stress |
| Zdroj: | Molecular Aspects of Medicine. 25:5-16 |
| ISSN: | 0098-2997 |
| DOI: | 10.1016/j.mam.2004.02.003 |
| Popis: | The scientific establishment has been discussing the relationship between aging and oxidative stress for quite some time now. While we are still far from a general agreement about this subject, there is an impressive amount of data collected that can be used to draw a compelling picture of the events that take place during the human aging process and their correlation with the oxidant status of the organism. In this review, we bring forth the results of some key studies that can help to elucidate the aging-oxidative stress puzzle, as well as to explain which are the fundamental events in this interplay and why their causal relationships remain so elusive. We also put forward here data on the systemic oxidative stress status of a group of 503 healthy human subjects. The data consist of the plasma levels of TBARS and of the nutritional antioxidants, alpha-tocopherol, beta-carotene and ascorbic acid, and of the activity of the antioxidant enzymes, Cu, Zn-superoxide dismutase, catalase and glutathione peroxidase, of red blood cells. The data indicate that a moderate situation of oxidative stress gradually develops during human aging. |
| Databáze: | OpenAIRE |
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