Exploring the binding interaction of calf thymus DNA with lapatinib, a tyrosine kinase inhibitor: multi-spectroscopic techniques combined with molecular docking

Autor:	Jie-Hua Shi, Ke-Ying Chen, Kai-Li Zhou, Yan-Yue Lou
Rok vydání:	2018
Předmět:	medicine.drug_class 030303 biophysics Lapatinib Binding Competitive Tyrosine-kinase inhibitor 03 medical and health sciences chemistry.chemical_compound Structural Biology medicine Animals Epidermal growth factor receptor skin and connective tissue diseases Protein Kinase Inhibitors Molecular Biology 0303 health sciences integumentary system biology Viscosity Chemistry Circular Dichroism Spectrum Analysis Osmolar Concentration DNA General Medicine Protein-Tyrosine Kinases Anticancer drug Molecular Docking Simulation Spectrometry Fluorescence Receptor tyrosine kinase inhibitor Cancer research biology.protein Nucleic Acid Conformation Thermodynamics Biological Assay Cattle Spectrophotometry Ultraviolet medicine.drug
Zdroj:	Journal of Biomolecular Structure and Dynamics. 37:576-583
ISSN:	1538-0254 0739-1102
DOI:	10.1080/07391102.2018.1433067
Popis:	Lapatinib, a double-target receptor tyrosine kinase inhibitor, is an oral-targeted anticancer drug developed by GlaxoSmithKline (GSK). It mainly acts on epidermal growth factor receptor 1 (EGFR1) a...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffd090a3f45a2e5f61f702928c998d2 https://doi.org/10.1080/07391102.2018.1433067 Zobrazit plný text záznamu