Regulation of Cell-Type-Specific Transcriptomes by miRNA Networks During Human Brain Development
| Autor: | Tomasz J. Nowakowski, Kylie Huch, Arnold R. Kriegstein, Neha Rani, Beatriz Alvarado, Jay A. A. West, Mahdi Golkaram, Alex A. Pollen, Hongjun Zhou, Anne A. Leyrat, Kenneth S. Kosik, Linda R. Petzold |
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| Rok vydání: | 2018 |
| Předmět: |
0303 health sciences
Messenger RNA Brain development Cell type specific Computational biology Human brain Biology Transcriptome 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure microRNA medicine Developmental biology 030217 neurology & neurosurgery 030304 developmental biology |
| Popis: | MicroRNAs (miRNAs) regulate many cellular events by regulating hundreds of mRNA transcripts. However, it is unclear how miRNA-mRNA interactions are contextualized into the framework of transcriptional heterogeneity among closely related cells of the developing human brain. By combining the multiple complementary approaches, AGO2-HITS-CLIP, single-cell profiling and bipartite network analysis, we show that the miRNA-mRNA network operates as functional modules related to cell-type identities and undergo dynamic transitions during brain development. |
| Databáze: | OpenAIRE |
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