Evaluation of a Liposome System for the Delivery of Desferrioxamine to Lungs in Rats
| Autor: | Arek Tabak, U. Taitelman, Erica Hoffer |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_treatment
Pharmaceutical Science Deferoxamine Pharmacology Dosage form Rats Sprague-Dawley Drug Delivery Systems Pharmacokinetics Macrophages Alveolar medicine Animals Lung Drug Carriers Liposome medicine.diagnostic_test business.industry Vesicle Vitamin E respiratory system Rats Bronchoalveolar lavage medicine.anatomical_structure Injections Intravenous Liposomes Immunology Female Drug carrier business |
| Zdroj: | Journal of Pharmacy and Pharmacology. 46:789-796 |
| ISSN: | 2042-7158 0022-3573 |
| Popis: | Liposomes with various lipid composition and sizes, prepared by two different techniques were evaluated for their potential to deliver desferrioxamine to lungs as a treatment against oxidative lung damage. Multilamellar vesicles (MLV) and reverse evaporation vesicles were prepared out of a lipid mixture containing dipalmitoyl phosphatidylcholine, stearyl amine, cholesterol and vitamin E. The administration of desferrioxamine-encapsulated liposomes to rats by the intravenous route at a dose of 100 mg kg−1, significantly prolonged the presence of desferrioxamine in all the tested organs when compared with the administration of free desferrioxamine. The injection of reverse evaporation vesicles extruded through a 2 μm polycarbonate membrane exhibited a longer residence time of the desferrioxamine and of liposomal vitamin E in lungs compared with the other types of liposomes tested. The examination of liposome components in the bronchoalveolar lavage fluid (BALF) and the alveolar macrophages recovered from BALF revealed that about 7 × 10−3% of the administered desferrioxamine dose was recovered by this technique at 3 and 17 h after liposome administration. This high residual concentration in the alveolar space confirms the hypothesis that liposomes can be delivered to the lung tissue when encapsulated in alveolar macrophages. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text