Biphasic material properties of lytic bone metastases
| Autor: | Jeffrey C. Lotz, Cari M. Whyne, Serena S. Hu, Kimberly L. Workman |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Stromal cell Chemistry Biomechanics Biomedical Engineering Aggregate modulus Bone Neoplasms In Vitro Techniques Skeleton (computer programming) Models Biological Biomechanical Phenomena Fractures Bone Lytic cycle Risk Factors Drug delivery Fracture (geology) Humans Female Stress Mechanical Material properties Biomedical engineering |
| Zdroj: | Annals of biomedical engineering. 28(9) |
| ISSN: | 0090-6964 |
| Popis: | It is necessary to prescribe the mechanical properties of tumor tissue when modeling the metastatically involved skeleton for clarifying the mechanisms of fracture. This study provides mechanical property data for lytic bone metastases. Specimens of human lytic tumor were tested under a confined compression uniaxial creep protocol and the mechanical behavior of the tumor tissue was modeled using linear biphasic theory. The tumor tissue was found to have an aggregate modulus (HA) of 3.6 +/- 1.6 kPa and a hydraulic permeability (k) of 0.59 +/- 0.46mm4 N(-1) s(-1). Tumors with a higher percentage of stromal content were found to be stiffer and more permeable than those with a more cellular composition. No significant differences in aggregate modulus or hydraulic permeability were found between lytic metastases of different types. These data are useful for the development of models to simulate the behavior of the metastatically involved skeleton using theoretical or finite-element analysis techniques and also have significance for developing effective tumor-drug-transport models. We anticipate that specification of the mechanical behavior of this tissue may help to better focus future treatment of lytic bony metastases through better assessment of fracture risk and improved drug delivery. |
| Databáze: | OpenAIRE |
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