Primary Pediatric Non-Hodgkin Lymphomas of the Gastrointestinal Tract: A Population-based Analysis
| Autor: | Adil Ayub, Buria Naeem |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Adolescent Cecal Neoplasms Population based Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms Internal medicine Epidemiology Humans Medicine Child Survival rate Gastrointestinal Neoplasms Gastrointestinal tract business.industry Lymphoma Non-Hodgkin Stomach Infant Newborn Infant General Medicine medicine.disease Burkitt Lymphoma Lymphoma Ileal Neoplasms Survival Rate Natural history medicine.anatomical_structure Oncology Child Preschool 030220 oncology & carcinogenesis Cohort Female Lymphoma Large B-Cell Diffuse business SEER Program |
| Zdroj: | Anticancer Research. 39:6413-6416 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.13855 |
| Popis: | BACKGROUND/AIM The aim of this study was to present the clinical characteristics, natural history and survival outcomes of primary gastrointestinal non-Hodgkin lymphomas (PGINHL) in the pediatric population. PATIENTS AND METHODS Surveillance, Epidemiology, and End Results (SEER) database was queried for patients aged 0 to 19 years with PGINHL between 1973 and 2014. RESULTS A total of 452 cases were identified [mean age 11.0 (±5.1)] years, whites 84.1%, males (76.5%). The majority of tumors were noted in the small bowel (SB) (47.6%), followed by large bowel (LB) (28.5%) and the stomach (10.0%). Overall, the most common histological subtype was Burkitt lymphoma (51.8%), followed by diffuse large B-cell lymphoma (DLBCL) (26.1%). Mean overall survival (OS) of the entire cohort was 33,33 years with a 5-yr, 10-yr and 30-yr survival rate of 86%, 86% and 79%, respectively. Large bowel tumors had the best long-term survival rates whereas; gastric tumors had the worst with 30-yr survival rate 84% and 74%, respectively. Overall, 328 (72.6%) patients received surgery. No significant survival difference was noted between patients who underwent surgery and those who did not. CONCLUSION This study presents the largest dataset of pediatric PGINHL and describes the clinical features and outcomes of these patients in addition to summarizing the literature. |
| Databáze: | OpenAIRE |
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