Evaluation of the 4-Pyridinemethanol WR 180,409 (Enpiroline) in the Treatment of Induced Plasmodium Falciparum Infections in Healthy, Non-Immune Subjects *
| Autor: | Charles L. Pamplin, Jonathan D. Berman, Moshe J. Shmuklarsky, Craig J. Canfield, Thomas M. Cosgriff, Ellen F. Boudreau |
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| Rok vydání: | 1984 |
| Předmět: |
Adult
ENPIROLINE Adolescent biology Pyridines Plasmodium falciparum Parasitemia Pharmacology medicine.disease biology.organism_classification Dose level Body weight Malaria Infectious Diseases Immune system Virology parasitic diseases Immunology medicine Day treatment Drug Evaluation Humans Parasitology |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 33:767-771 |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.1984.33.767 |
| Popis: | WR 180,409 (enpiroline) was administered to 22 non-immune subjects infected with the multi-drug resistant Vietnam Smith isolate of Plasmodium falciparum. It was curative in single day treatment regimens with a minimum curative dose of approximately 10 mg/kg body weight. At this dose level it was well tolerated and produced rapid clearance of parasitemia in every case. |
| Databáze: | OpenAIRE |
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