Iron supplementation does not worsen respiratory health or alter the sputum microbiome in cystic fibrosis
| Autor: | Katherine E. Price, Thomas H. Hampton, Dana B. Dorman, Zhigang Li, George A. O'Toole, Bruce A. Stanton, H. Worth Parker, Diana M. Alexandru, Mitchell L. Sogin, Jonathan B. Zuckerman, Alex H. Gifford, Lisa A. Moulton |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Adolescent Cystic Fibrosis Anemia Cystic fibrosis-related diabetes Cystic fibrosis Article Placebos Young Adult Double-Blind Method Hepcidins medicine Humans Microbiome Ferrous Compounds Pediatrics Perinatology and Child Health Lung Cross-Over Studies biology Anemia Iron-Deficiency business.industry Microbiota Sputum Iron deficiency Middle Aged medicine.disease Cystic fibrosis transmembrane conductance regulator medicine.anatomical_structure Treatment Outcome Pediatrics Perinatology and Child Health Immunology biology.protein Female medicine.symptom business |
| Zdroj: | Journal of Cystic Fibrosis. 13(3):311-318 |
| ISSN: | 1569-1993 |
| DOI: | 10.1016/j.jcf.2013.11.004 |
| Popis: | Iron supplementation for hypoferremic anemia could potentiate bacterial growth in the cystic fibrosis (CF) lung, but clinical trials testing this hypothesis are lacking.Twenty-two adults with CF and hypoferremic anemia participated in a randomized, double-blind, placebo-controlled, crossover trial of ferrous sulfate 325mg daily for 6weeks. Iron-related hematologic parameters, anthropometric data, sputum iron, Akron Pulmonary Exacerbation Score (PES), and the sputum microbiome were serially assessed. Fixed-effect models were used to describe how ferrous sulfate affected these variables.Ferrous sulfate increased serum iron by 22.3% and transferrin saturation (TSAT) by 26.8% from baseline (p0.05) but did not affect hemoglobin, sputum iron, Akron PES, and the sputum microbiome.Low-dose ferrous sulfate improved hypoferremia without correcting anemia after 6weeks. We did not observe significant effects on sputum iron, Akron PES, and the sputum microbiome. Although we did not identify untoward health effects of iron supplementation, a larger blinded randomized controlled trial would be needed to fully demonstrate safety. |
| Databáze: | OpenAIRE |
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