Maternal n-3 PUFAs deficiency during pregnancy inhibits neural progenitor cell proliferation in fetal rat cerebral cortex
| Autor: | Hong-Bin Li, Bao-Qiang Guo, Shi-Bin Ding |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Cyclin E Apoptosis Biology 03 medical and health sciences 0302 clinical medicine Fetus Developmental Neuroscience Neural Stem Cells Pregnancy Internal medicine Cyclins Fatty Acids Omega-3 medicine Animals Progenitor cell Rats Wistar 030304 developmental biology Cell Proliferation chemistry.chemical_classification Cerebral Cortex 0303 health sciences Fatty Acids food and beverages Maternal Nutritional Physiological Phenomena medicine.disease eye diseases Neural stem cell Diet Rats medicine.anatomical_structure Endocrinology chemistry Cerebral cortex lipids (amino acids peptides and proteins) Female 030217 neurology & neurosurgery Developmental Biology Polyunsaturated fatty acid |
| Zdroj: | International journal of developmental neuroscience : the official journal of the International Society for Developmental NeuroscienceReferences. 76 |
| ISSN: | 1873-474X |
| Popis: | The aim of this study was to evaluate the in vivo impacts of maternal n-3 polyunsaturated fatty acids (PUFAs) deficiency during pregnancy on the proliferation of neural progenitor cells (NPCs) in the developing cerebral cortex of fetal rats. Our results showed that about 5 weeks of maternal dietary n-3 PUFAs deprivation resulted in a substantial n-3 PUFA deficiency in fetal rat cerebral cortex. Importantly, by two survival schemes and two quantitative methods, we found that maternal intake of n-3 PUFAs deficient diet during the gestation significantly inhibited the proliferation of NPCs in fetal rat cerebral cortex. Moreover, the decreased cortical NPCs proliferation induced by nutritional n-3 PUFAs restriction did not originate from the increased NPCs apoptosis. Finally, our observations indicated that the down-regulation of cyclin E protein might be involved in the inhibitory effects of maternal n-3 PUFAs deficient diet on the proliferation of cortical NPCs. These findings highlight the importance of maternal intake of appropriate n-3 PUFAs and deepen our understanding of the exact effects of n-3 PUFAs on mammalian brain development. |
| Databáze: | OpenAIRE |
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