Advancement in CRISPR/Cas9 Technology to Better Understand and Treat Neurological Disorders

Autor: Aishika, Datta, Deepaneeta, Sarmah, Harpreet, Kaur, Antra, Chaudhary, Namrata, Vadak, Anupom, Borah, Sudhir, Shah, Xin, Wang, Pallab, Bhattacharya
Rok vydání: 2022
Předmět:
Zdroj: Cellular and Molecular Neurobiology. 43:1019-1035
ISSN: 1573-6830
0272-4340
DOI: 10.1007/s10571-022-01242-3
Popis: Neurological disorders have complicated pathophysiology that may involve several genetic mutations. Conventional treatment has limitations as they only treat apparent symptoms. Although, personalized medicine is emerging as a promising neuro-intervention, lack of precision is the major pitfall. Clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 system is evolving as a technological platform that may overcome the therapeutic limitations towards precision medicine. In the future, targeting genes in neurological disorders may be the mainstay of modern therapy. The present review on CRISPR/Cas9 and its application in various neurological disorders may provide a platform for its future clinical relevance towards developing precise and personalized medicine.
Databáze: OpenAIRE
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