Intense Pulsed Light: A Methodical Approach to Understanding Clinical Endpoints
| Autor: | Douglas C. Wu, Michael B Lipp, Kunal Angra, Mitchel P. Goldman |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Erythema medicine.medical_treatment Fitzpatrick Skin Type III Skin Pigmentation Cosmetic Techniques Intense pulsed light Single-Case Studies as Topic Clinical endpoint Photography Medicine Humans Rejuvenation Prospective Studies Aged Skin Hypopigmentation Vena cava filters Back Pulse (signal processing) business.industry Photorejuvenation Intense Pulsed Light Therapy Pulse duration Alopecia General Medicine Treatment Outcome medicine.symptom business Biomedical engineering Follow-Up Studies |
| Zdroj: | Journal of drugs in dermatology : JDD. 20(2) |
| ISSN: | 1545-9616 |
| Popis: | Background Intense Pulsed Light (IPL) is a non-coherent polychromatic broadband filtered flashlamp that emits light in the spectrum of approximately 400n1200 nm. Its effects on photorejuvenation are well documented. The goal of this study is to help practitioners better conceptualize and fine tune IPL device settings in order to produce the most effective and safest clinical outcome. Materials/methods This was a prospective study testing several filters (515 nm; 560 nm; 590 nm and 530n650; 900n1200 nm vascular filter), fluences, pulse durations, and pulse numbers (ie, multiple sequence pulsing or MSP) with a new IPL system. Results Post-procedure erythema response was more pronounced with increasing fluence, decreasing wavelength, fewer pulses and shorter pulse duration. The exception was the 515 nm filter with regard to pulse duration, which was observed to have a more pronounced response with longer pulse durations. The overall clinical outcome at the 4-week follow-up visit demonstrated greatest improvement in erythema and pigmentation using the 515 nm filter on a Fitzpatrick Skin Type III individual. Conclusion Greatest clinical endpoint response at 4-week follow-up was observed with more robust initial responses. This was most apparent at higher fluence levels and fewer pulse counts. However, when the IPL is pushed to aggressive parameters, there is risk of hypopigmentation and hair loss as seen in this case study. Skin type is an important consideration when using IPL and MSP adds to its safety profile. J Drugs Dermatol. 2021;20(2):203-207. doi:10.36849/JDD.5638. |
| Databáze: | OpenAIRE |
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