Role of TCR ζ Chain in T Cell Development and Selection
| Autor: | Eric Lee, Elizabeth W. Shores, Alexander Grinberg, Paul E. Love, Tom Tran, Kun Huang |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte CD8 Antigens T-Lymphocytes Transgene Cellular differentiation T cell Molecular Sequence Data Receptors Antigen T-Cell Down-Regulation Gene Expression Mice Transgenic chemical and pharmacologic phenomena Thymus Gland Biology CD5 Antigens Mice Antigens CD medicine Animals Lectins C-Type Amino Acid Sequence RNA Messenger Receptor Homeodomain Proteins Genetics Multidisciplinary T-cell receptor Membrane Proteins Proteins hemic and immune systems T lymphocyte Cell biology DNA-Binding Proteins Thymocyte medicine.anatomical_structure CD4 Antigens Lymph Nodes Signal transduction Signal Transduction |
| Zdroj: | Science. 266:1047-1050 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Signals mediated by the T cell receptor (TCR) are required for thymocyte maturation and selection. To examine the role of TCR zeta chain signals in development, TCR expression was restored in zeta-deficient mice with transgenic zeta chains that partially or completely lacked sequences required for signal transduction. The zeta chain played a role in thymic development by promoting TCR surface expression, but zeta-mediated signals were not essential because TCRs that contained signaling-deficient zeta chains promoted T cell maturation and transduced signals associated with thymic selection. |
| Databáze: | OpenAIRE |
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