Anatomical correlates of rapid eye movement sleep-dependent plasticity in the developing cortex

Autor: Marcos G. Frank, Tammi Coleman, Michelle C.D. Bridi, Lutgarde Arckens, Leslie Renouard
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
sleep function
Rapid eye movement sleep
Clinical Neurology
brain development
Biology
ocular dominance
03 medical and health sciences
0302 clinical medicine
SYNAPTIC PLASTICITY
PARADOXICAL SLEEP
Physiology (medical)
mental disorders
Neuroplasticity
PONTINE-WAVE GENERATOR
VISUAL-CORTEX
synaptic remodeling
Arc (protein)
Science & Technology
MOLECULAR-MECHANISMS
musculoskeletal
neural
and ocular physiology
DORSAL HIPPOCAMPUS
Neurosciences
DEPRIVATION IMPAIRS
Eye movement
Long-term potentiation
Sleep in non-human animals
030104 developmental biology
REM-SLEEP
Synaptic plasticity
Developmental plasticity
Neurology (clinical)
Neurosciences & Neurology
LONG-TERM POTENTIATION
CORTICAL PLASTICITY
Neuroscience
Life Sciences & Biomedicine
030217 neurology & neurosurgery
psychological phenomena and processes
Popis: Rapid eye movement (REM) sleep is expressed at its highest levels during early life when the brain is rapidly developing. This suggests that REM sleep may play important roles in brain maturation and developmental plasticity. We investigated this possibility by examining the role of REM sleep in the regulation of plasticity-related proteins known to govern synaptic plasticity in vitro and in vivo. We combined immunohistochemistry with a classic model of experience-dependent plasticity in the developing brain known to be consolidated during sleep. We found that after the developing visual cortex is triggered to remodel, it is reactivated during REM sleep (as measured by FOS+ and ARC+ cells). This is accompanied by expression of several proteins implicated in synaptic long-term potentiation (PSD95 and phosphorylated (p), mTOR, cofilin, and CREB) across the different cortical layers. These changes did not occur in animals deprived of REM sleep, but were preserved in control animals that were instead awakened in non- (N) REM sleep. Collectively, these findings support a role for REM sleep in developmental brain plasticity. ispartof: Sleep vol:41 issue:10 pages:1-11 ispartof: location:United States status: published
Databáze: OpenAIRE
Externí odkaz: