Cardiac sympathetic activity in response to acute myocardial ischemia
| Autor: | Gary E. Newton, Allan G. Adelman, Erick Schampaert, V. C. Lima, John D. Parker, P. H. Seidelin |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Sympathetic nervous system Sympathetic Nervous System Physiology medicine.medical_treatment Myocardial Ischemia Ischemia Blood Pressure Anterior Descending Coronary Artery Norepinephrine (medication) Norepinephrine Heart Rate Coronary Circulation Physiology (medical) Angioplasty Internal medicine medicine Humans business.industry Middle Aged medicine.disease Autonomic nervous system Epinephrine medicine.anatomical_structure Anesthesia Catecholamine Cardiology Female Cardiology and Cardiovascular Medicine business Angioplasty Balloon medicine.drug |
| Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology. 272:H2079-H2084 |
| ISSN: | 1522-1539 0363-6135 |
| Popis: | Although experimental evidence has demonstrated that brief periods of myocardial ischemia are not associated with norepinephrine overflow from the heart, cardiac sympathetic responses to myocardial ischemia in humans remain unclear. Eleven patients undergoing angioplasty of the left anterior descending coronary artery had cardiac norepinephrine spillover measured immediately before inflation, during the final minute of a 5-min balloon inflation, and 1 min after deflation. Angioplasty caused significant S-T segment elevation and a reduction in the transcardiac lactate extraction ratio. Cardiac norepinephrine spillover was reduced from a mean value of 58 +/- 14 pmol/min at control to 41 +/- 15 pmol/min during balloon inflation and 38 +/- 14 pmol/min after deflation (P < 0.05 vs. control for both inflation and deflation values). In contrast, during balloon inflation, there were significant increases in arterial norepinephrine and epinephrine concentrations. Therefore, a brief period of myocardial ischemia caused by angioplasty of the left anterior descending coronary artery does not result in cardiac sympathetic activation, despite evidence of generalized sympathoadrenal activation. |
| Databáze: | OpenAIRE |
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