The effect of obesity on acute kidney injury after cardiac surgery
| Autor: | Anna Marie Murphy, Denise M. Sadlier, John S Byrne, John Hurley, Katie E O'Sullivan, Amy Hudson |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Body Mass Index law.invention chemistry.chemical_compound Risk Factors law Internal medicine Cardiopulmonary bypass Humans Medicine Obesity Myocardial infarction Cardiac Surgical Procedures Aged Retrospective Studies Creatinine Cardiopulmonary Bypass business.industry Incidence Acute kidney injury Retrospective cohort study Odds ratio Acute Kidney Injury Middle Aged medicine.disease Cardiac surgery chemistry Cardiology Female Surgery Cardiology and Cardiovascular Medicine business Body mass index |
| Zdroj: | The Journal of Thoracic and Cardiovascular Surgery. 150:1622-1628 |
| ISSN: | 0022-5223 |
| DOI: | 10.1016/j.jtcvs.2015.08.082 |
| Popis: | Objective Postoperative acute kidney injury is a frequent and serious consequence of cardiac surgery. We undertook to investigate the association of obesity and the risk of acute kidney injury development after cardiac surgery. Methods A total of 432 patients who underwent cardiac surgery with cardiopulmonary bypass between October 2009 and August 2010 were included in the final retrospective analysis. Obesity was defined as body mass index 30 kg/m 2 or greater. Acute kidney injury was defined as a creatinine increase of 25% or more from baseline at 48 hours after surgery. Results The overall incidence of acute kidney injury was 29.9% (n = 129). There was an increased incidence of postoperative renal impairment in the obese versus nonobese cohort; however, this was not statistically significant (39% vs 25.9%, P = .007). Multivariate logistic regression revealed that body mass index 30 kg/m 2 or greater was independently associated with the development of postoperative acute kidney injury (odds ratio [OR], 2.12; 95% confidence interval [CI], 1.27-3.54; P = .004), as were age (OR, 0.98; 95% CI, 0.96-1.0; P = .04) and cardiopulmonary bypass time (OR, 0.99; 95% CI, 0.98-1.0; P = .048). Conclusions Obesity with body mass index 30 kg/m 2 or greater is independently associated with an increased risk of acute kidney injury after cardiac surgery. Further understanding of the molecular basis of this association is critical to the design of preventative strategies. |
| Databáze: | OpenAIRE |
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