Doppler analysis and placental nitric oxide synthase expression during fetal growth restriction
| Autor: | Andrea L. Tranquilli, Hisanori Suzuki, Stefano Raffaele Giannubilo, Elisa Tedeschi, Marta Menegazzi, Valeria Bezzeccheri |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
medicine.medical_specialty Endothelium Nitric Oxide Synthase Type III Placenta Doppler analysis Nitric Oxide Synthase Type II fetal growth restriction Syncytiotrophoblast Enos Pregnancy medicine.artery Internal medicine Laser-Doppler Flowmetry Medicine Humans Placental Circulation Fetal Growth Retardation biology business.industry Uterus Obstetrics and Gynecology Umbilical artery biology.organism_classification Nitric oxide synthase iNOS eNOS medicine.anatomical_structure Endocrinology Regional Blood Flow Case-Control Studies Pediatrics Perinatology and Child Health biology.protein Female business |
| Popis: | To assess placental nitric oxide (NO) metabolism related to changes in the uteroplacental circulation during fetal growth restriction (FGR).The resistance index (RI) from the uterine arteries and pulsatility index (PI) from the umbilical artery were determined by Doppler analysis in 15 patients with FGR and 12 healthy controls, before elective cesarean section. Inducible (iNOS) and endothelial (eNOS) NO synthase expression were measured in placental samples. Immunohistochemistry was performed for iNOS location in the placenta.During FGR, we observed a significant elevation of iNOS when compared with controls. Conversely, eNOS did not differ between the two groups. A negative correlation with eNOS (r = -0.85) and a positive correlation with iNOS (r = 0.91) was found correlating to umbilical PI. The iNOS proteins were reduced in syncytiotrophoblast cells and increased in endothelium in the FGR group compared to the controls.During FGR, placental iNOS expression is significantly increased; this increase possibly represents an adaptive physiological mechanism for overcoming a fetoplacental circulation deficiency. |
| Databáze: | OpenAIRE |
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