Dietary Fiber-Induced Microbial Short Chain Fatty Acids Suppress ILC2-Dependent Airway Inflammation
| Autor: | Omid Akbari, Bowen Wang, Hadi Maazi, Gerrold Bongers, Pedram Shafiei Jahani, Richard Lo, German R. Aleman Muench, Virender K. Rehan, Pejman Soroosh, Emily Howard, Homayon Banie, Lani San-Mateo, Swetha Santosh, Andrew Baltus, Doumet Georges Helou, Gavin Lewis, Benjamin P. Hurrell, Frank D. Gilliland, Lauriane Galle-Treger |
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| Rok vydání: | 2019 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Dietary Fiber 0301 basic medicine Neutrophils Immunology short chain fatty acid Inflammation Context (language use) Butyrate Gut flora ILC2 Allergic inflammation Mice 03 medical and health sciences 0302 clinical medicine medicine Animals Immunology and Allergy Glycolysis Lymphocytes Original Research Mice Knockout Mice Inbred BALB C biology Chemistry Short-chain fatty acid Innate lymphoid cell respiratory system biology.organism_classification Asthma Immunity Innate Gastrointestinal Microbiome respiratory tract diseases 3. Good health allergic disease 030104 developmental biology Butyric Acid airway hyperreactivity medicine.symptom lcsh:RC581-607 030215 immunology |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 10 (2019) |
| ISSN: | 1664-3224 |
| Popis: | Group 2 Innate lymphoid cells (ILC2) contribute significantly to allergic inflammation. However, the role of microbiota on ILC2s remains to be unraveled. Here we show that short chain fatty acids (SCFAs), such as butyrate, derived from fermentation of dietary fibers by the gut microbiota inhibit pulmonary ILC2 functions and subsequent development of airway hyperreactivity (AHR). We further show that SCFAs modulate GATA3, oxidative phosphorylation, and glycolytic metabolic pathways in pulmonary ILC2s. The observed phenotype is associated with increased IL-17a secretion by lung ILC2s and linked to enhanced neutrophil recruitment to the airways. Finally, we show that butyrate-producing gut bacteria in germ-free mice effectively suppress ILC2-driven AHR. Collectively, our results demonstrate a previously unrecognized role for microbial-derived SCFAs on pulmonary ILC2s in the context of AHR. The data suggest strategies aimed at modulating metabolomics and microbiota in the gut, not only to treat, but to prevent lung inflammation and asthma. |
| Databáze: | OpenAIRE |
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