Very low rate of type I collagen synthesis and degradation in newly diagnosed children with acute lymphoblastic leukemia
| Autor: | S.-M. Kivivuori, Eino Marttinen, Leila Risteli, Ritva Sorva, Martti A. Siimes, Juha Risteli, Markku Turpeinen, A. Sorva |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Histology Adolescent Physiology Endocrinology Diabetes and Metabolism medicine.medical_treatment Lymphoblastic Leukemia Induction Phase Antineoplastic Agents Newly diagnosed Statistics Nonparametric 03 medical and health sciences 0302 clinical medicine N-terminal telopeptide Acute lymphocytic leukemia Internal medicine Medicine Humans Longitudinal Studies Child 030304 developmental biology 0303 health sciences Chemotherapy business.industry Infant Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Peptide Fragments Leukemia Endocrinology 030220 oncology & carcinogenesis Child Preschool Immunology Female Collagen business Type I collagen Procollagen |
| Zdroj: | Bone. 20(2) |
| ISSN: | 8756-3282 |
| Popis: | In children with acute lymphoblastic leukemia (ALL), the metabolism of type I collagen, the major collagen of bones, may be changed at diagnosis and during early chemotherapy. In the present study, bone formation and degradation rates were evaluated longitudinally in 35 children with ALL, using two serum markers of bone collagen formation: the amino-terminal (PINP) and carboxyterminal (PICP) propeptides; and a marker of degradation: the carboxyterminal telopeptide of type I collagen (ICTP). These serum markers were determined at diagnosis, during induction treatment (at 1, 4, and 6 weeks), and during consolidation treatment (at 8 and 12 weeks). The changes in the serum markers suggested that, at diagnosis, type I collagen turnover (i.e., both synthesis and degradation) was remarkably low. The median serum levels of PINP, PICP, and ICTP were -2.6 SDS (standard deviation score), -1.5 SDS, and -2.5 SDS, respectively. The PICP and PINP levels declined further during the first week of therapy (p < 0.001), whereas the ICTP levels had risen by end of the induction phase (p < 0.05). By the end of the 12 week interval, the concentrations of the formation and degradation markers had returned to normal (p < 0.01). Our findings suggest that ALL is accompanied by low turnover of bone collagen. The abnormalities are at first aggravated, but then corrected, by treatment. |
| Databáze: | OpenAIRE |
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