A Retrospective Study of the Effects of Psychotropic Drugs on Neuroendocrine Hormones in Patients with Bipolar Disorder
| Autor: | Bo Zhang, Xueli Sun, Shengnan Zhao |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
bipolar disorder
medicine.medical_specialty Neuropsychiatric Disease and Treatment business.industry Incidence (epidemiology) neuroendocrine hormones Retrospective cohort study medicine.disease psychotropic drugs Hypothalamic–pituitary–thyroid axis 030227 psychiatry 03 medical and health sciences 0302 clinical medicine Endocrinology Psychotropic drug Internal medicine medicine In patient Neuroendocrine hormone Bipolar disorder business 030217 neurology & neurosurgery Original Research Hormone |
| Zdroj: | Neuropsychiatric Disease and Treatment |
| ISSN: | 1178-2021 |
| DOI: | 10.2147/ndt.s306458 |
| Popis: | Background Bipolar disorder (BD) is predominantly treated with medication, and previous studies have shown that psychotropic drugs have an effect on the neuroendocrine system. And the objectives of this study were: 1) to assess changes in neuroendocrine hormones of HPA axis and HPT axis in patients with BD after psychotropic drug treatment; 2) to determine differences in the above neuroendocrine hormones between psychotropic drug monotherapy and polytherapy treated patients. Methods This study was a retrospective study that included 188 subjects. Results After psychotropic drugs treatment, TSH levels increased significantly from baseline (p Conclusion Although the incidence of significant HPT axis and HPA axis dysfunction after psychotropic drug treatment is low in patients with BD who have normal baseline neuroendocrine hormone levels, psychotropic drug treatment does suppress HPT axis and HPA axis function irrespective of the use of psychotropic drugs alone or in combination, and duration of psychotropic drug treatment. Therefore, even patients with BD who have normal baseline levels of neuroendocrine hormones should have their neuroendocrine hormone levels regularly monitored after psychotropic drug medication. But, the interval of monitoring can be slightly longer, which can be once every six months after taking psychotropic drugs. |
| Databáze: | OpenAIRE |
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