Antiviral and Anticoagulant Activities of a Water-Soluble Fraction of the Marine Diatom Haslea ostrearia
| Autor: | Gerhard Franz, J. M. Robert, Susanne Alban, Nathalie Bourgougnon, F. Pojer, Jean Claude Chermann, Jean-Pascal Bergé, S. Billaudel |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Anti-HIV Agents
Carbohydrates Pharmaceutical Science Herpesvirus 1 Human Biology Pharmacognosy Antiviral Agents Cell Line Analytical Chemistry Microbiology Multiplicity of infection Chlorocebus aethiops Drug Discovery Animals Humans Cytotoxicity Vero Cells EC50 Diatoms Pharmacology Plant Extracts Organic Chemistry Anticoagulants Biological activity In vitro Complementary and alternative medicine Cell culture Vero cell Molecular Medicine |
| Zdroj: | Planta Medica. 65:604-609 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-1999-14032 |
| Popis: | A water-soluble fraction from the marine diatom Haslea ostrearia was capable to inhibit the in vitro replication of HSV-1 in Vero cells with 50% inhibitory concentration (EC50) of 14 micrograms/ml at a multiplicity of infection of 0.01 ID50/cells. In addition, this fraction delayed the HIV-1-induced syncitia formation on MT4 cells. At concentrations up to 200 micrograms/ml, no cytotoxicity was observed for both the Vero and MT4 cells. The fraction only inhibited the blood coagulation process at concentrations considerably exceeding the EC50. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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