Vitamin D Receptor Gene Polymorphisms and Epithelial Ovarian Cancer Risk
| Autor: | Michael E. Carney, Galina Lurie, Marc T. Goodman, Katharine McDuffie, Keith Terada, Lynne R. Wilkens, Pamela J. Thompson |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Genotype Epidemiology Biology Polymerase Chain Reaction Calcitriol receptor Gastroenterology Risk Factors Ovarian carcinoma Internal medicine medicine Vitamin D and neurology Humans Genetic Predisposition to Disease Neoplasms Glandular and Epithelial Allele Aged Aged 80 and over Ovarian Neoplasms Polymorphism Genetic Racial Groups Cancer Odds ratio Middle Aged medicine.disease Endocrinology Oncology Case-Control Studies Receptors Calcitriol Female Ovarian cancer |
| Zdroj: | Cancer Epidemiology, Biomarkers & Prevention. 16:2566-2571 |
| ISSN: | 1538-7755 1055-9965 |
| DOI: | 10.1158/1055-9965.epi-07-0753 |
| Popis: | Epidemiologic and laboratory studies support a role for the vitamin D endocrine system in ovarian carcinogenesis. The association of ovarian cancer risk with polymorphisms in the vitamin D receptor (VDR) gene, including rs10735810 (FokI), rs11568820 (Cdx-2), rs1544410 (BsmI), rs7975232 (ApaI), rs731236 (TaqI), and BsmI-ApaI-TaqI combined genotypes, was examined among 313 women with epithelial ovarian carcinoma and 574 controls. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using unconditional logistic regression. The associations of VDR polymorphisms with risk were generally inconsistent across ethnic groups. Among Caucasian women (72 cases, 148 controls), heterozygous and homozygous ApaI A allele carriers were at increased ovarian carcinoma risk compared with homozygous carriers of the ApaI a allele (OR 2.8, 95% CI 1.2-7.0 and OR 3.4, 95% CI 1.3-9.1; Ptrend = 0.02). Caucasian heterozygous carriers of FokI f allele were also at increased risk of ovarian carcinoma compared with homozygous carriers of the common allele (OR 2.5, 95% CI 1.3-4.8; Ptrend = 0.04). Among Japanese women (94 cases, 173 controls), ovarian cancer risk was significantly decreased (OR 0.5, 95% CI 0.3-0.9) among Cdx-2 A allele heterozygotes compared with homozygote G allele carriers (Ptrend = 0.03). Compared with the bbaaTT BsmI-ApaI-TaqI genotype, bbaATT and BBAAtt genotypes were associated with increased ovarian cancer risk in Caucasian women (OR 4.2, 95% CI 1.3-13.1 and OR 5.2, 95% CI 1.6-17.5), but not in Japanese women (OR 1.1, 95% CI 0.6-1.9 and OR 2.3, 95% CI:0.4-12.3). This investigation provides some evidence that polymorphisms in the VDR gene might influence ovarian cancer susceptibility. (Cancer Epidemiol Biomarkers Prev 2007;16(12):2566–71) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|