Myeloradiculitis caused by Cryptococcus neoformans infection in a patient with ulcerative colitis: A neuropathological study
| Autor: | Jun Ichi Kira, Ikuko Kubo, Takayuki Taniwaki, Hideaki Tokunaga, Masakazu Kawajiri, Toru Iwaki, Hiroyuki Murai |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Pathology medicine.medical_specialty Fulminant Meningitis Cryptococcal Flucytosine Myelopathy Amphotericin B medicine Humans Staining and Labeling business.industry Meninges Meningoencephalitis Middle Aged medicine.disease Ulcerative colitis medicine.anatomical_structure Spinal Cord Neurology Cryptococcus neoformans Colitis Ulcerative Neurology (clinical) business Meningitis medicine.drug |
| Zdroj: | Journal of the Neurological Sciences. 247:236-238 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/j.jns.2006.05.050 |
| Popis: | Meningitis is the most common feature of cryptococcal infection of the nervous system. We herein describe the case of a 48-year-old man with fulminant cryptococcal myeloradiculitis, whose initial symptoms were impotence, dysuria and weakness of the lower extremities. He had been administered prednisolone and azathioprine for 7 years for ulcerative colitis before onset of myeloradiculitis. He finally developed meningoencephalitis and died 2 months after onset despite treatment with amphotericin B and flucytosine. Post-mortem examination revealed numerous infiltrations of cryptococci in the spinal roots as well as in the meninges and subarachnoid space. Inflammatory cells and cryptococci had infiltrated the vessel walls in the spinal cord, and this was accompanied by necrotizing myelopathy. Myeloradiculitis is rare in cryptococcal infection, and this is the first case report to demonstrate direct cryptococcal infection in the spinal roots. Cryptococcal infection should be considered while managing myeloradiculopathy of unknown etiology, especially in immunocompromised patients. |
| Databáze: | OpenAIRE |
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