18F-2-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography Scanning Affects Surgical Management in Selected Patients With High-Risk, Operable Breast Carcinoma
| Autor: | Henry Yeung, Laura Liberman, Patrick I. Borgen, James F. Caravelli, Steven M. Larson, Elisa Port, Mithat Gonen |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
medicine.medical_specialty 18f 2 fluoro 2 deoxy d glucose Bone Neoplasms Breast Neoplasms Extent of disease Computed tomographic Breast cancer Fluorodeoxyglucose F18 Surgical oncology medicine Humans Prospective Studies Neoplasm Metastasis Aged medicine.diagnostic_test business.industry Middle Aged medicine.disease Bone scanning Treatment Outcome Oncology Patient Satisfaction Positron emission tomography Female Surgery Radiology Radiopharmaceuticals Tomography X-Ray Computed Breast carcinoma Nuclear medicine business Tomography Emission-Computed |
| Zdroj: | Annals of Surgical Oncology. 13:677-684 |
| ISSN: | 1534-4681 1068-9265 |
| DOI: | 10.1245/aso.2006.03.035 |
| Popis: | The role of positron emission tomography (PET) scanning in determining the extent of disease in patients with breast cancer has not been defined. We investigated the utility of (18)F-2-fluoro-2-deoxy-D: -glucose (FDG)-PET scanning compared with conventional imaging with computed tomographic scanning and bone scanning in determining the extent of disease in patients with high-risk, operable breast cancer.This was a prospective study of patients who presented to Memorial Sloan-Kettering Cancer Center for operative treatment of breast cancer. Eighty eligible patients were enrolled and underwent computed tomographic chest, abdomen, pelvis, and bone scans, followed by FDG-PET. Changes in treatment based on scan findings were recorded by the operating surgeons. Imaging findings were verified by biopsy or long-term follow-up.Eight (10%) of 80 patients were found to have metastatic disease that was seen on both conventional imaging and PET. Four additional patients (5%) had additional foci of disease on PET that affected treatment decisions. No patient had findings on conventional imaging alone. Conventional imaging studies resulted in a higher number of findings that generated additional tests and biopsies that ultimately had negative results (17% vs. 5% for PET). There was a statistically significant difference in specificity for PET compared with conventional imaging (P = .01).Conventional imaging and PET were equally sensitive in detecting metastatic disease in patients with high-risk, operable breast cancer, but PET generated fewer false-positive results. FDG-PET scanning should be further studied in this setting and considered in the preoperative evaluation of selected patients with breast cancer. |
| Databáze: | OpenAIRE |
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