Extracts of Leptadenia hastata Leaf, a Famine Food and Traditional Remedy for Furuncles, Suppress Inflammation in Murine Models
Autor: | Peter A. Akah, Ifechukwu Kenneth Ufere, Charles Ogbonnaya Okoli, A. C. Ezike, S. C. Ezea |
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Rok vydání: | 2015 |
Předmět: |
0301 basic medicine
Leptadenia hastata medicine.drug_class Phytochemicals Anti-Inflammatory Agents Vascular permeability Inflammation Carrageenan 01 natural sciences Anti-inflammatory Capillary Permeability Lethal Dose 50 Rats Sprague-Dawley 03 medical and health sciences Acetic acid chemistry.chemical_compound Mice Formaldehyde medicine Toxicity Tests Acute Animals Edema Pharmacology (medical) Acetic Acid Nutrition and Dietetics Granuloma Traditional medicine Chemistry Plant Extracts Arthritis Furunculosis Famine food 0104 chemical sciences Apocynaceae Plant Leaves 010404 medicinal & biomolecular chemistry Disease Models Animal 030104 developmental biology Biochemistry Phytochemical medicine.symptom Food Science |
Zdroj: | Journal of dietary supplements. 13(2) |
ISSN: | 1939-022X |
Popis: | The effects of the methanol extract (LHE), hexane (LHHF), ethylacetate (LHEF) and methanol (LHMF) fractions of leaf of Leptadenia hastata on acute and chronic inflammation were studied. Furthermore, the effects of LHE on acetic acid induced increase in vascular permeability, carrageenan induced leucocyte migration and membrane stability were evaluated. The LHE and fractions were also subjected to phytochemical analysis. The LHE, LHEF and LHMF significantly (p0.05) suppressed topical ear edema, systemic paw edema, global edematous response to formaldehyde arthritis and granuloma tissue growth. The LHE suppressed acetic acid induced vascular permeability and carrageenan-induced leucocyte migration, and also stabilized the erythrocyte membrane. An acute toxicity test in mice established an oral LD505 g/kg for LHE. The LHEF elicited the greatest inhibition, suggesting that the observed anti-inflammatory effects may be attributable to the flavonoids abundant in the fraction. These findings demonstrate that the effectiveness of L. hastata leaf in the treatment of furuncles may largely derive from anti-inflammatory activities mediated through inhibition of both increase in vascular permeability and leucocyte migration, and stabilization of cell membranes. |
Databáze: | OpenAIRE |
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