Chemoselective Dimerization of Phosphates
| Autor: | Alexandre Hofer, Michael O. Hottiger, Sara Jordi, Thérésa Bridget Fitzpatrick, Sarah-Kirsten N Gatter, Nicole Kieliger, Elia Marques, Henning J. Jessen, Elena Ferrari, Manuel Hofmann |
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| Přispěvatelé: | University of Zurich, Jessen, Henning J |
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Cytidine triphosphate 1303 Biochemistry 010405 organic chemistry Stereochemistry Organic Chemistry food and beverages 010402 general chemistry 01 natural sciences Biochemistry 10226 Department of Molecular Mechanisms of Disease 0104 chemical sciences chemistry.chemical_compound Adenosine diphosphate ddc:580 chemistry 570 Life sciences biology Nucleotide Thiamine Physical and Theoretical Chemistry 1606 Physical and Theoretical Chemistry Adenosine triphosphate human activities 1605 Organic Chemistry |
| Zdroj: | Organic Letters Organic Letters, Vol. 18, No 13 (2016) pp. 3222-3225 |
| ISSN: | 1523-7060 |
| DOI: | 10.1021/acs.orglett.6b01466 |
| Popis: | A methodology for the synthesis of oligophosphate conjugates using phosphordiamidites is described. This strategy facilitates the straightforward preparation of C2-symmetric dinucleoside tri-, penta-, and heptaphosphates. Moreover, unsymmetric compounds such as thiamine adenosine triphosphate and thiamine cytidine triphosphate can be prepared. The material is used to study the inhibitory activity of thiaminylated nucleotides against adenosine diphosphate ribosyltransferases. |
| Databáze: | OpenAIRE |
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