EphB2 Guides Axons at the Midline and Is Necessary for Normal Vestibular Function
| Autor: | Mark Henkemeyer, Bernd Fritzsch, Nobuhiko Yokoyama, Chad A. Cowan, Lynne M. Bianchi |
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| Rok vydání: | 2000 |
| Předmět: |
Receptor
EphB2 Endolymph Neuroscience(all) Efferent Growth Cones PDZ domain Stereotypic Movement Disorder Vestibular Nerve Receptor tyrosine kinase Mice Neurons Efferent otorhinolaryngologic diseases medicine Animals Inner ear Ephrin B3 Cochlear Nerve Vestibular system biology General Neuroscience Receptor Protein-Tyrosine Kinases Embryo Mammalian Vestibular nerve Axons Semicircular Canals Cell biology Rhombencephalon medicine.anatomical_structure Ear Inner Mutation biology.protein Vestibule Labyrinth sense organs Neuroscience |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/s0896-6273(00)81174-5 |
| Popis: | Mice lacking the EphB2 receptor tyrosine kinase display a cell-autonomous, strain-specific circling behavior that is associated with vestibular phenotypes. In mutant embryos, the contralateral inner ear efferent growth cones exhibit inappropriate pathway selection at the midline, while in mutant adults, the endolymph-filled lumen of the semicircular canals is severely reduced. EphB2 is expressed in the endolymph-producing dark cells in the inner ear epithelium, and these cells show ultrastructural defects in the mutants. A molecular link to fluid regulation is provided by demonstrating that PDZ domain–containing proteins that bind the C termini of EphB2 and B-ephrins can also recognize the cytoplasmic tails of anion exchangers and aquaporins. This suggests EphB2 may regulate ionic homeostasis and endolymph fluid production through macromolecular associations with membrane channels that transport chloride, bicarbonate, and water. |
| Databáze: | OpenAIRE |
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