Theophylline infusion modulates prostaglandin and leukotriene production in man
| Autor: | István Mucha, Erkki Seppälä, Seppo Kaukinen, T. Kerttula, J. Alanko, Asko Riutta, Pauli Ylitalo |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Leukotrienes medicine.medical_specialty Thromboxane Clinical Biochemistry Leukotriene Production Blood Pressure Prostacyclin 030204 cardiovascular system & hematology Dinoprostone 03 medical and health sciences chemistry.chemical_compound Thromboxane A2 0302 clinical medicine Theophylline Heart Rate Internal medicine medicine Humans 030212 general & internal medicine Infusions Intravenous Calcimycin Leukotriene E4 Leukotriene Cell Biology Bronchodilator Agents 3. Good health Thromboxane B2 Endocrinology chemistry Prostaglandins medicine.drug |
| Zdroj: | Prostaglandins, Leukotrienes and Essential Fatty Acids. 57:555-560 |
| ISSN: | 0952-3278 |
| DOI: | 10.1016/s0952-3278(97)90560-3 |
| Popis: | Although theophylline has been used in the treatment of asthma for decades, it is not a first line choice any more. It is a well-known bronchodilator, but was recently discovered also to be an anti-inflammatory, immunomodulatory and bronchoprotective agent. Therefore we wanted to establish the role of theophylline on prostaglandin and leukotriene production, which plays a part in the pathogenesis of asthma. Theophylline was infused (bolus 5 mg/kg in 15 min and infusion 0.4 mg/kg/h for 1 h 45 min) into healthy volunteers. Thromboxane B2, prostaglandin E2 and leukotriene E4 were measured from the A23187-stimulated whole blood samples and stable metabolites of thromboxane A2; prostacyclin and leukotriene E4 were measured from urine. Theophylline increased prostaglandin E2 production and decreased leukotriene E4 production ex vivo in whole blood, thus increasing the prostanoid/leukotriene ratio. It did not change thromboxane B2 production stimulated by either spontaneous clotting or A23187 in the whole blood. Theophylline had hardly any effect on in vivo thromboxane, prostacyclin and leukotriene E4 production measured as urinary metabolites, 11-dehydro-thromboxane B2, 2,3-dinor-6-keto-prostaglandin F1alpha and leukotriene E4, respectively. Serum theophylline concentrations were at the lower level of normal therapeutic range during the infusion. The increase in PGE2 and the decrease in LTE4 synthesis ex vivo may offer a new explanation for the mode of antiasthmatic action of theophylline. It is notable that this phenomenon occurs at low serum theophylline concentrations. These results confirm the idea that theophylline has an anti-inflammatory and bronchoprotective action and support the use of theophylline as a therapeutic agent in asthmatic patients. |
| Databáze: | OpenAIRE |
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