Highly Selective Hydrogenation of C═C Bonds Catalyzed by a Rhodium Hydride
| Autor: | Jack R. Norton, Farbod Salahi, Zhiyao Zhou, Yiting Gu, Scott A. Snyder, Vladislav G. Lisnyak |
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| Rok vydání: | 2021 |
| Předmět: |
Double bond
chemistry.chemical_element Alkenes 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry Article Catalysis Rhodium chemistry.chemical_compound Colloid and Surface Chemistry Alkanes Organometallic Compounds chemistry.chemical_classification Natural product Chemistry Hydride General Chemistry Highly selective 0104 chemical sciences Models Chemical Homogeneous Hydrogenation |
| Zdroj: | J Am Chem Soc |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/jacs.1c04683 |
| Popis: | Under mild conditions (room temperature, 80 psi of H(2)) Cp*Rh(2-(2-pyridyl)phenyl)H catalyzes the selective hydrogenation of the C═C bond in α,β-unsaturated carbonyl compounds, including natural product precursors with bulky substituents in the β position and substrates possessing an array of additional functional groups. It also catalyzes the hydrogenation of many isolated double bonds. Mechanistic studies reveal that no radical intermediates are involved, and the catalyst appears to be homogeneous, thereby affording important complementarity to existing protocols for similar hydrogenation processes. |
| Databáze: | OpenAIRE |
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