Studies on the State of Insulin in Blood

Autor:	Harry N. Antoniades, Hugh M. Pyle, James A. Bougas, Rafael A. Camerini-Davalos, Kare Gundersen
Rok vydání:	1962
Předmět:	medicine.medical_specialty business.industry Insulin medicine.medical_treatment General Medicine medicine.disease Peripheral medicine.anatomical_structure Endocrinology Diabetes mellitus Internal medicine Diabetes Mellitus medicine Humans Pancreas Vein business Fasting state
Zdroj:	New England Journal of Medicine. 267:953-957
ISSN:	1533-4406 0028-4793
DOI:	10.1056/nejm196211082671902
Popis:	EXPERIMENTAL studies, reported elsewhere, presented data on the relative amounts of "free" insulin and insulin complexes in the splenic, portal, hepatic and peripheral vein blood of diabetic and nondiabetic subjects.1 2 3 4 It was shown that insulin is secreted from the pancreas of both diabetic and nondiabetic subjects in the "free," biologically active form within minutes of intravenous administration of glucose.4 In the peripheral vein blood of nondiabetic subjects the insulin appeared both in the "free" form and as an inactive complex, the ratio depending on the metabolic state.2 3 4 In the fasting state the predominant form of insulin in blood circulated as . . .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fdc28545a78295f1629e3a61f12d4ff https://doi.org/10.1056/nejm196211082671902 Zobrazit plný text záznamu