Haptoglobin directly affects T cells and suppresses T helper cell type 2 cytokine release
| Autor: | Erik Stevens, P. Matthijs, Ahmad Kasran, Jan Ceuppens, Mohamed Arredouani, E. M. Van Hoeyveld, Heinz Baumann |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.drug_class
medicine.medical_treatment Immunology Dose-Response Relationship Immunologic CD8-Positive T-Lymphocytes Lymphocyte Activation medicine.disease_cause Monoclonal antibody Autoimmunity Mice Th2 Cells Immune system Adjuvants Immunologic Tumor Cells Cultured medicine Animals Immunology and Allergy Phytohemagglutinins Mice Knockout Haptoglobins biology Haptoglobin Original Articles T helper cell Th1 Cells In vitro Cell biology Mice Inbred C57BL Cytokine medicine.anatomical_structure biology.protein Cytokines Cell Division CD8 |
| Zdroj: | Immunology. 108:144-151 |
| ISSN: | 1365-2567 0019-2805 |
| DOI: | 10.1046/j.1365-2567.2003.01569.x |
| Popis: | Summary T helper cell type 1 (Th1) and type 2 (Th2) immune responses are characterized by a different pattern of cytokine expression following T-cell activation. Alterations of the ratio of Th1 to Th2 cells are important determinants of susceptibility to viral and parasitic infections, allergies, anti-tumour responses, and autoimmunity. In this work we bring new evidence for an effect of haptoglobin (Hp), a positive acute-phase protein, on T-lymphocyte functions. We show that Hp specifically interacts with both resting and activated CD4+ and CD8+ T cells. This specific binding results in a strong suppression of induced T-cell proliferation. In addition, Hp exhibits a strong in vitro inhibitory effect on Th2 cytokine release, while the production of interferon-γ (IFN-γ) and interleukin-2 (IL-2) is only slightly inhibited at high Hp doses. As a result, the presence of Hp promotes Th1 activation over Th2 activation in vivo as evidenced in Hp-deficient mice. Anti-CD3 monoclonal antibody injection indeed resulted in predominant IL-4 production in Hp−/− mice, in contrast to predominant IFN-γ production in Hp+/+ mice. We conclude that Hp plays a modulating role on the Th1/Th2 balance by promoting a dominant Th1 cellular response. This points to a role of acute-phase proteins in balancing immune responses. |
| Databáze: | OpenAIRE |
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