Practical Synthesis of Quinoxalinones via Palladium-Catalyzed Intramolecular N-Arylations
| Autor: | Etienne Chénard, Tomaszewski Miroslaw, Xuehong Luo, Cheng Yun-Xing, Peter Martens |
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| Rok vydání: | 2010 |
| Předmět: |
Molecular Structure
Bicyclic molecule Chemistry Organic Chemistry chemistry.chemical_element Biochemistry Combinatorial chemistry Catalysis Cyclization Quinoxalines Yield (chemistry) Intramolecular force Microwave irradiation Combinatorial Chemistry Techniques Physical and Theoretical Chemistry Microwaves Palladium |
| Zdroj: | Organic Letters. 12:3574-3577 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | A practical and highly efficient route to the synthesis of pharmaceutically interesting quinoxalinone scaffolds is reported. The key step involves an intramolecular palladium-catalyzed N-arylation under microwave irradiation. The developed methodology tolerates a variety of bromoanilides to afford a diverse collection of bicyclic and polycyclic quinoxalinones in high yield. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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