Genetic polymorphisms for BDNF, COMT, and APOE do not affect gait or ankle motor control in chronic stroke: A preliminary cross-sectional study
| Autor: | Rehab Aljuhni, Brice T. Cleland, Stephen M. Roth, Sangeetha Madhavan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Apolipoprotein E 030506 rehabilitation medicine.medical_specialty Adolescent Genotype Cross-sectional study Catechol O-Methyltransferase Affect (psychology) Article Young Adult 03 medical and health sciences Apolipoproteins E 0302 clinical medicine Physical medicine and rehabilitation Humans Medicine Stroke Chronic stroke Gait Disorders Neurologic Aged Aged 80 and over Chicago Community and Home Care Movement Disorders Polymorphism Genetic business.industry Brain-Derived Neurotrophic Factor Rehabilitation Motor control Middle Aged Prognosis medicine.disease Gait Cross-Sectional Studies medicine.anatomical_structure Chronic Disease Female Neurology (clinical) Ankle 0305 other medical science business 030217 neurology & neurosurgery |
| Zdroj: | Top Stroke Rehabil |
| ISSN: | 1945-5119 1074-9357 |
| Popis: | BACKGROUND: Motor deficits after stroke are a primary cause of long-term disability. The extent of functional recovery may be influenced by genetic polymorphisms. OBJECTIVES: Determine the effect of genetic polymorphisms for brain-derived neurotrophic factor (BDNF), catechol-O-methyltransferase (COMT), and apolipoprotein E (APOE) on walking speed, walking symmetry, and ankle motor control in individuals with chronic stroke. METHODS: 38 participants with chronic stroke were compared based upon genetic polymorphisms for BDNF (presence [MET group] or absence [VAL group] of a Met allele), COMT (presence [MET group] or absence [VAL group] of a Met allele), and APOE (presence [ε4+ group] of absence [ε4- group] of ε4 allele). Comfortable and maximal walking speed were measured with the 10-meter walk test. Gait spatiotemporal symmetry was measured with the GAITRite electronic mat; symmetry ratios were calculated for step length, step time, swing time, and stance time. Ankle motor control was measured as the accuracy of performing an ankle tracking task. RESULTS: No significant differences were detected (p≥0.11) between the BDNF, COMT, or APOE groups for any variables. CONCLUSIONS: In these preliminary findings, genetic polymorphisms for BDNF, COMT, and APOE do not appear to affect walking speed, walking symmetry, or ankle motor performance in chronic stroke. |
| Databáze: | OpenAIRE |
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