Incidence of multiple sclerosis in the general population in the Netherlands, 1996-2008
| Autor: | M C J M Sturkenboom, N.A.T. van der Maas, J.M. Kemmeren, H.E. de Melker, E M van Soest, M A Kramer |
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| Přispěvatelé: | Medical Informatics |
| Rok vydání: | 2012 |
| Předmět: |
Vaccine safety
Adult Male Pediatrics medicine.medical_specialty Multiple Sclerosis Adolescent Databases Factual Epidemiology Population Cohort Studies Age Distribution SDG 3 - Good Health and Well-being medicine Humans Sex Distribution education Aged Netherlands Retrospective Studies education.field_of_study business.industry Multiple sclerosis Incidence (epidemiology) Active monitoring Incidence Retrospective cohort study Middle Aged medicine.disease Physical therapy Age distribution Female Neurology (clinical) business Cohort study |
| Zdroj: | Neuroepidemiology, 39(2), 96-102. Karger |
| ISSN: | 1423-0208 0251-5350 |
| Popis: | Background: We estimated the multiple sclerosis (MS) incidence in the Netherlands for better active monitoring of potential vaccine safety signals. Methods: A retrospective cohort study (1996–2008) was conducted using a population-based general practice research database containing electronic medical records. Additional information was collected to validate incident probable cases. Results: In the source population (648,656 persons), 146 incident probable MS cases were identified. Overall incidence rate was 6.3/100,000 person years (py; 95% CI, 5.2–7.2). In the subgroup in which MS could be fully validated, the incidence increased from 4/100,000 py (95% CI, 3–5) in 1996–2004 to 9/100,000 py in 2007/8 (95% CI, 6–16). This increase was highest among women, but not statistically significantly different by gender. The median lag time between first recorded symptoms and MS diagnosis decreased from 32 months (2005). Conclusions: MS is rare in the Netherlands. In recent years, there was a slight increase in the incidence especially among women during the fertile age. This increase coincided with a decrease in lag time between symptoms and diagnosis, both for men and women. This trend should be taken into account in the interpretation of MS cases occurring in a population where new vaccinations will be introduced shortly. |
| Databáze: | OpenAIRE |
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